NDLI: Body mass index, tumor characteristics, and prognosis following diagnosis of early-stage breast cancer in a mammographically screened population

Content Provider	Springer Nature Link
Author	Kamineni, Aruna Anderson, Melissa L. White, Emily Taplin, Stephen H. Porter, Peggy Ballard Barbash, Rachel Malone, Kathleen Buist, Diana S. M.
Copyright Year	2012
Abstract	Many studies suggest increased body mass index (BMI) is associated with worse breast cancer outcomes, but few account for variability in screening, access to treatment, and tumor differences. We examined the association between BMI and risk of breast cancer recurrence, breast cancer-specific mortality, and all-cause mortality, and evaluated whether tumor characteristics differ by BMI among a mammographically screened population with access to treatment.Using a retrospective cohort study design, we followed 485 women aged ≥40 years diagnosed with stage I/II breast cancer within 24 months of a screening mammogram occurring between 1988 and 1993 for 10-year outcomes. BMI before diagnosis was categorized as normal (<25 kg/m2), overweight (25–29.9 kg/m2), and obese (≥30 kg/m2). Tumor marker expression was assessed via immunohistochemistry using tissue collected before adjuvant treatment. Medical records were abstracted to identify treatment, recurrence, and mortality. We used Cox proportional hazards to separately model the hazard ratios (HR) of our three outcomes by BMI while adjusting for age, stage, and tamoxifen use.Relative to normal-weight women, obese women experienced increased risk of recurrence (HR 2.43; 95 % CI 1.34–4.41) and breast cancer death (HR 2.41; 95 % CI 1.00–5.81) within 10 years of diagnosis. There was no association between BMI and all-cause mortality. Obese women had significantly faster growing tumors, as measured by Ki-67.Our findings add to the growing evidence that obesity may contribute to poorer breast cancer outcomes, and also suggest that increased tumor proliferation among obese women is a pathway that explains part of their excess risk of adverse outcomes.
Starting Page	305
Ending Page	312
Page Count	8
File Format	PDF
ISSN	09575243
Journal	Cancer Causes & Control
Volume Number	24
Issue Number	2
e-ISSN	15737225
Language	English
Publisher	Springer Netherlands
Publisher Date	2012-12-07
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Breast cancer recurrence Breast cancer-specific mortality Tumor characteristics Obesity Body mass index Cancer Research Biomedicine general Oncology Public Health Epidemiology Hematology
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Body mass index, tumor characteristics, and prognosis following diagnosis of early stage breast cancer in a mammographically-screened population

Pre-diagnosis body mass index, post-diagnosis weight change, and prognosis among women with early stage breast cancer

Post-diagnosis adiposity and survival among breast cancer patients: influence of breast cancer subtype

Associations of pre-diagnostic body mass index with overall and cancer-specific mortality in a large Austrian cohort

Influence of body mass index on prognosis in gynecological malignancies

Prostatic fatty acids and cancer recurrence after radical prostatectomy for early-stage prostate cancer

Body mass index and weight change in relation to triple-negative breast cancer survival

Season of diagnosis and prognosis in breast and prostate cancer

Relationship between prostate-specific antigen, age, and body mass index in a prostate cancer screening population.

Body mass index, tumor characteristics, and prognosis following diagnosis of early-stage breast cancer in a mammographically screened population

Similar Documents

Body mass index, tumor characteristics, and prognosis following diagnosis of early stage breast cancer in a mammographically-screened population

Pre-diagnosis body mass index, post-diagnosis weight change, and prognosis among women with early stage breast cancer

Post-diagnosis adiposity and survival among breast cancer patients: influence of breast cancer subtype

Associations of pre-diagnostic body mass index with overall and cancer-specific mortality in a large Austrian cohort

Influence of body mass index on prognosis in gynecological malignancies

Prostatic fatty acids and cancer recurrence after radical prostatectomy for early-stage prostate cancer

Body mass index and weight change in relation to triple-negative breast cancer survival

Season of diagnosis and prognosis in breast and prostate cancer

Relationship between prostate-specific antigen, age, and body mass index in a prostate cancer screening population.

Body mass index, tumor characteristics, and prognosis following diagnosis of early-stage breast cancer in a mammographically screened population