NDLI: Dietary intake of acrylamide and esophageal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort

Content Provider	Springer Nature Link
Author	Lujan Barroso, Leila González, Carlos Alberto Slimani, Nadia Obón Santacana, Mireia Ferrari, Pietro Freisling, Heinz Overvad, Kim Clavel Chapelon, Françoise Boutron Ruault, Marie Christine Racine, Antoine Katzke, Verena Kühn, Tilman Tjønneland, Anne Olsen, Anja Quirós, J. Ramón Sánchez Cantalejo, Emilio Amia, Pilar Navarro, Carmen Barricarte, Aurelio Khaw, Kay Tee Wareham, Nick Travis, Ruth C. Trichopoulou, Antonia Bamia, Christina Benetou, Vassiliki Saieva, Calogero Grioni, Sara Tumi, Rosario Vineis, Paolo Mattiello, Amalia Bue de Mesquita, H. Bas Siersema, Peter D. Numans, Mattijs E. Peeters, Petra H. Ericson, Ulrika Wirfält, Elisabet Sund, Malin Johansson, Mattias Weiderpass, Elisabete Skeie, Guri Riboli, Elio Boeing, Heiner Duell, Eric J.
Copyright Year	2014
Abstract	The relation between dietary acrylamide intake and esophageal cancer (EC) risk, including esophageal adenocarcinoma (EAC) and esophageal squamous cell carcinoma (ESCC), has not been consistent. We evaluated the association between dietary acrylamide intake and EAC, ESCC, and overall EC in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.Multivariate Cox proportional hazards models were used to estimate the HR and 95 % confidence interval (95 % CI). Since nonlinear relations were observed, HRs were displayed for quartiles of acrylamide intake in μg per day.After a mean follow-up of 11 years, 341 EC were identified, 142 of which were EAC, 176 ESCC, and 23 other histological types or not specified. An increase in EC risk was observed in the second and third quartiles (HRQ2vsQ1 1.75, 95 % CI 1.12–2.74; HRQ3vsQ1 1.66, 95 % CI 1.05–2.61), but not in the fourth quartile, and there was no evidence for a linear dose–response trend. HRs were similarly elevated but not statistically significant when ESCC and EAC were analyzed separately, due to the small number of cases observed. No associations were observed when quartiles were based on energy-adjusted acrylamide intake.In the EPIC cohort, an association between estimated dietary acrylamide intake and an increased risk of developing EC was observed in the middle quartiles but not in the highest quartile; however, results from other larger cohorts or consortia, and results from biomarker studies, might add to the evidence provided by this analysis, suggesting that acrylamide is not an important risk factor for EC.
Starting Page	639
Ending Page	646
Page Count	8
File Format	PDF
ISSN	09575243
Journal	Cancer Causes & Control
Volume Number	25
Issue Number	5
e-ISSN	15737225
Language	English
Publisher	Springer International Publishing
Publisher Date	2014-02-16
Publisher Place	Cham
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Esophageal cancer Esophageal squamous cell carcinoma Esophageal adenocarcinoma Acrylamide intake Cohort Nutrition Cancer Research Biomedicine general Oncology Public Health Epidemiology Hematology
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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