NDLI: Association between human papillomavirus and adenocarcinoma of rectum and recto-sigmoid junction: a cohort study of 10,612 women in Taiwan

Content Provider	Springer Nature Link
Author	Chuang, Li Chung Chen, Hui Chi You, San Lin Lin, Ching Yu Pan, Mei Hung Chou, Yi Chun Hsieh, Chang Yao Chen, Chien Jen
Copyright Year	2010
Abstract	This study aimed at assessing the association between the type-specific human papillomavirus (HPV) infection and the risk of adenocarcinoma of the rectum and recto-sigmoid junction. A total of 10,612 women aged 30–65 years old were enrolled from seven townships in Taiwan. Cervical cells collected at study entry were tested for 39 types of HPV infection by polymerase chain reactions and HPV blot kit. Newly developed adenocarcinomas of rectum and recto-sigmoid junction were ascertained through computerized linkage with national cancer registry profiles. An increased risk of adenocarcinomas of the rectum and recto-sigmoid junction was observed with HPV infection, showing a hazard ratio [HR] (95% confidence interval [CI]) of 1.99 (0.98–4.04) after adjustment for age and body mass index. The adjusted HR (95% CI) for the infection of HPV types other than 6 and 11 was 2.18 (1.04–4.60). Women with cervical infection of HPV types other than 6 and 11 at study entry may have an increased risk of adenocarcinomas of the rectum and recto-sigmoid junction, which deserves further validation by large-scale studies.
Starting Page	2123
Ending Page	2128
Page Count	6
File Format	PDF
ISSN	09575243
Journal	Cancer Causes & Control
Volume Number	21
Issue Number	12
e-ISSN	15737225
Language	English
Publisher	Springer Netherlands
Publisher Date	2010-08-19
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Human papillomavirus Adenocarcinoma Rectum Hematology Epidemiology Public Health/Gesundheitswesen Oncology Biomedicine general Cancer Research
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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