NDLI: Family history of hematologic malignancies and risk of multiple myeloma: differences by race and clinical features

Content Provider	Springer Nature Link
Author	VanValkenburg, MaryAnn E. Pruitt, Gwendolyn I. Brill, Ilene K. Costa, Lucia Ehtsham, Maryam Justement, Ian T. Innis Shelton, Racquel D. Salzman, Donna Reddy, E. Shyam P. Godby, Kelly N. Mikhail, Fady M. Carroll, Andrew J. Reddy, Vishnu B. Sanderson, Ralph D. Justement, Louis B. Sanders, Paul W. Brown, Elizabeth E.
Copyright Year	2015
Abstract	Multiple myeloma (MM) is the most common hematologic malignancy affecting Blacks in the USA, with standardized incidence rates that are twofold to threefold higher than Whites. The rationale for the disparity is unclear.Using participants enrolled in the Molecular And Genetic Epidemiology study of myeloma (259 MM cases; 461 controls), we examined the risk of MM associated with family history of cancer, differences by race and among cases, defining clinical features. Risk estimates were calculated using odds ratios and corresponding 95% confidence intervals from logistic regression adjusted for confounders.Overall, MM risk in cases with relatives affected with any hematologic malignancy was significantly elevated compared to controls (OR 1.89, 95% CI 1.25–2.86). Myeloma risk associated with a family history of MM was higher than the risk associated with any hematologic malignancy (OR 3.75, 95% CI 1.75–8.05), and the effect was greater for Blacks (OR 20.9, 95% CI 2.59–168) than Whites (OR 2.04, 95% 0.83–5.04), among cases with early onset (≤60 years; OR 4.58, 95% CI 1.21–17.3) and with increasing numbers of affected relatives (p trend = 0.001). Overall, frequencies of end organ damage differed in cases with relatives affected with any hematologic malignancy and significantly more cases exhibited κ light chain restriction (OR 3.23, 95% CI 1.13–9.26).The excess risk of MM observed in Blacks and the variation in clinical features observed in MM patients according to family history of hematologic malignancy may be attributed to a shared germline and environmental susceptibility.
Starting Page	81
Ending Page	91
Page Count	11
File Format	PDF
ISSN	09575243
Journal	Cancer Causes & Control
Volume Number	27
Issue Number	1
e-ISSN	15737225
Language	English
Publisher	Springer International Publishing
Publisher Date	2015-11-23
Publisher Place	Cham
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Multiple myeloma Family history Genetic Black African American Cancer Research Biomedicine general Oncology Public Health Epidemiology Hematology
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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