NDLI: Polymorphisms in oxidative stress and inflammation pathway genes, low-dose ionizing radiation, and the risk of breast cancer among US radiologic technologists

Content Provider	Springer Nature Link
Author	Schonfeld, Sara J. Bhatti, Parveen Brown, Elizabeth E. Linet, Martha S. Simon, Steven L. Weinstock, Robert M. Hutchinson, Amy A. Stovall, Marilyn Preston, Dale L. Alexander, Bruce H. Doody, Michele M. Sigurdson, Alice J.
Copyright Year	2010
Abstract	Ionizing radiation, an established breast cancer risk factor, has been shown to induce oxidative damage and chronic inflammation. Polymorphic variation in oxidative stress and inflammatory-mediated pathway genes may modify radiation-related breast cancer risk.We estimated breast cancer risk for 28 common variants in 16 candidate genes involved in these pathways among 859 breast cancer cases and 1,083 controls nested within the US Radiologic Technologists cohort. We estimated associations between occupational and personal diagnostic radiation exposures with breast cancer by modeling the odds ratio (OR) as a linear function in logistic regression models and assessed heterogeneity of the dose–response across genotypes.There was suggestive evidence of an interaction between the rs5277 variant in PTGS2 and radiation-related breast cancer risk. The excess OR (EOR)/Gy from occupational radiation exposure = 5.5 (95%CI 1.2–12.5) for the GG genotype versus EOR/Gy < 0 (95%CI < 0–3.8) and EOR/Gy < 0 (95%CI < 0–14.8) for the GC and CC genotypes, respectively, (p interaction = 0.04). The association between radiation and breast cancer was not modified by other SNPs examined.This study suggests that variation in PTGS2 may modify the breast cancer risk from occupational radiation exposure, but replication in other populations is needed to confirm this result.
Starting Page	1857
Ending Page	1866
Page Count	10
File Format	PDF
ISSN	09575243
Journal	Cancer Causes & Control
Volume Number	21
Issue Number	11
e-ISSN	15737225
Language	English
Publisher	Springer Netherlands
Publisher Date	2010-08-15
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	PTGS2 COX-2 Inflammation Breast cancer Radiation Hematology Epidemiology Public Health/Gesundheitswesen Oncology Biomedicine general Cancer Research
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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Polymorphisms in oxidative stress and inflammation pathway genes, low-dose ionizing radiation, and the risk of breast cancer among US radiologic technologists

Breast cancer risk polymorphisms and interaction with ionizing radiation among U.S. Radiologic Technologists

POLYMORPHISMS IN ESTROGEN BIOSYNTHESIS AND METABOLISM-RELATED GENES, IONIZING RADIATION EXPOSURE, AND RISK OF BREAST CANCER AMONG U.S. RADIOLOGIC TECHNOLOGISTS

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Polymorphisms in oxidative stress and inflammation pathway genes, low-dose ionizing radiation, and the risk of breast cancer among US radiologic technologists

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