NDLI: Predictors of fasting serum insulin and glucose and the risk of pancreatic cancer in smokers

Content Provider	Springer Nature Link
Author	Meinhold, Cari L. Gonzalez, Amy Berrington Albanes, Demetrius Weinstein, Stephanie J. Taylor, Philip R. Virtamo, Jarmo Stolzenberg Solomon, Rachael Z.
Copyright Year	2008
Abstract	A history of type 2 diabetes is one of few consistent risk factors for pancreatic cancer. Potentially modifiable factors related to fasting insulin and glucose concentrations may influence pancreatic cancer risk.Multiple linear regression models were used to identify anthropometric, clinical, behavioral, and dietary factors associated with fasting insulin and glucose in a subcohort of non-diabetics in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (n = 366). Hazards ratios (HRs) and 95% confidence intervals (CIs) were calculated among the larger cohort (n = 27,035).During follow-up (median 16.1 years), 305 participants developed pancreatic cancer. Fasting insulin and/or glucose were positively associated with body mass index (BMI), height, and dietary total and saturated fat and inversely associated with serum high-density lipoprotein cholesterol (HDL) and dietary available carbohydrates, sucrose, and alcohol. Comparing highest to lowest quintiles, total fat (HR = 1.54, 95% CI 1.05–2.25, p-trend = 0.01) and saturated fat (HR = 1.38, 95% CI 0.97–1.98, p-trend = 0.06) were positively associated and available carbohydrates (HR = 0.63, 95% CI 0.44–0.90, p-trend = 0.01), particularly sucrose (HR = 0.62, 95% CI 0.43–0.89, p-trend = 0.09), were inversely associated with risk of pancreatic cancer. BMI, HDL, height, and alcohol were not associated with pancreatic cancer risk.Dietary fat is associated with higher fasting insulin concentrations and may increase pancreatic cancer risk in smokers.
Starting Page	681
Ending Page	690
Page Count	10
File Format	PDF
ISSN	09575243
Journal	Cancer Causes & Control
Volume Number	20
Issue Number	5
e-ISSN	15737225
Language	English
Publisher	Springer Netherlands
Publisher Date	2008-12-13
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Insulin resistance Pancreatic cancer Lifestyle factors Nutrition Anthropometry Hematology Epidemiology Public Health/Gesundheitswesen Oncology Biomedicine general Cancer Research
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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