NDLI: Past medical conditions and K-ras mutations in pancreatic ductal adenocarcinoma: a hypothesis-generating study

Content Provider	Springer Nature Link
Author	Crous Bou, Marta Porta, Miquel Morales, Eva López, Tomàs Carrato, Alfredo Puigdomènech, Elisa Real, Francisco X.
Copyright Year	2008
Abstract	In pancreatic ductal adenocarcinoma (PDA) evidence on the etiopathogenic role of past medical conditions in the occurrence and persistence of K-ras mutations is scant.Incident cases of PDA were interviewed face-to-face about past medical history and other factors. Logistic regression was used to compare PDA cases (n = 120) with wild-type and mutated K-ras tumors (case–case study).Patients with wild-type K-ras tumors were more likely to have a prior diagnosis of pancreatitis (Odds ratio [OR] = 6.11, p = 0.041). Diabetes mellitus (DM) was non-significantly more common among cases with a K-ras wild-type tumor, and the OR for DM of >6 years of duration was 4.54 (p = 0.39). Patients with wild-type K-ras were significantly more likely to have had a surgically treated peptic ulcer (OR = 9.03, p = 0.027). The probability of having a K-ras wild-type tumor increased with the number of medical conditions (p for trend = 0.012); the corresponding OR for two or more medical conditions was 4.46 (95% CI: 1.37–14.50).Results raise the hypothesis that pancreatitis and possibly peptic ulcer might influence pancreatic carcinogenesis through pathways independent of K-ras mutation, perhaps related to growth factors or mediators of the inflammatory response. Large unselected studies should be conducted to refute or replicate our findings.
Starting Page	591
Ending Page	599
Page Count	9
File Format	PDF
ISSN	09575243
Journal	Cancer Causes & Control
Volume Number	20
Issue Number	5
e-ISSN	15737225
Language	English
Publisher	Springer Netherlands
Publisher Date	2008-12-13
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Medical conditions Diabetes mellitus Pancreatitis Peptic ulcer Pancreatic ductal adenocarcinoma Pancreatic neoplasms Etiology K-ras oncogene Hematology Epidemiology Public Health/Gesundheitswesen Oncology Biomedicine general Cancer Research
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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