NDLI: Vitamin D, PTH, and calcium in relation to survival following prostate cancer

Content Provider	Springer Nature Link
Author	Brändstedt, Johan Almquist, Martin Manjer, Jonas Malm, Johan
Copyright Year	2016
Abstract	Epidemiological studies suggest that low levels of vitamin D constitute a risk factor for prostate cancer. However, the results are conflicting, perhaps because prostate cancer is a very heterogeneous disease. More recent studies have focused on cancer progression and mortality. Vitamin D is closely related to both calcium metabolism and parathyroid hormone (PTH) levels, and all three factors have been implicated in prostate cancer.We examined the associations between pre-diagnostic serum levels of vitamin D (25OHD), PTH, and calcium and mortality among 943 participants within the Malmö Diet and Cancer Study, who were diagnosed with prostate cancer. The mean time from diagnosis until the end of followup was 9.1 years (SD 4.5), and the mean time from inclusion until end of follow-up was 16.6 years (SD 4.9). The analytes were divided into quartiles, and the risk of death from prostate cancer was analyzed using Cox proportional hazard analysis, yielding hazards ratios (HR) with 95 % confidence intervals. The models were adjusted for season and year of inclusion, age at baseline, age at diagnosis, body mass index (BMI), and tumor characteristics (TNM and Gleason score).We observed a trend toward a lower prostate-specific mortality with 25OHD >85 nmol/L in the unadjusted analysis. This became statistically significantly in the third quartile of 25OHD (85–102 nmol/L) compared to the first (<68 nmol/L), HR 0.54 (0.34–0.85) when adjusting for age, time of inclusion, and BMI. The association was further strengthened when adjusted for age at diagnosis, Gleason score, and TNM classification with a HR in Q3 0.36 (0.22–0.60). p for trend was 0.03. Regarding calcium, there was a significantly lower HR for the second quartile (2.35–2.39 mmol/L) compared to the first (≤2.34 mmol/L) with a HR of 0.54 (0.32–0.86) in the unadjusted analysis. However, this association disappeared when adjusting for tumor characteristics. There were no associations between levels of PTH and prostate cancer mortality.This study shows that levels of pre-diagnostic vitamin D above 85 nmol/L may improve survival in men with prostate cancer.
Starting Page	669
Ending Page	677
Page Count	9
File Format	PDF
ISSN	09575243
Journal	Cancer Causes & Control
Volume Number	27
Issue Number	5
e-ISSN	15737225
Language	English
Publisher	Springer International Publishing
Publisher Date	2016-03-29
Publisher Place	Cham
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Vitamin D PTH Calcium Prostate cancer Mortality Cancer Research Biomedicine general Oncology Public Health Epidemiology Hematology
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Serum levels of vitamin D, parathyroid hormone and calcium in relation to survival following breast cancer

Vitamin D, PTH, and calcium and tumor aggressiveness in prostate cancer: a prospective nested case–control study

Vitamin D, PTH, and calcium and the risk of prostate cancer: a prospective nested case–control study

The epidemiology of vitamin D and cancer incidence and mortality: A review (United States)

Serum 25-OH vitamin D levels and risk of developing prostate cancer in older men

Adolescent dietary vitamin D and sun exposure in relation to benign breast disease

Coffee and tea consumption in relation to prostate cancer prognosis

Fat intake after prostate cancer diagnosis and mortality in the Physicians’ Health Study

Seasonal variation in expression of markers in the vitamin D pathway in prostate tissue

Vitamin D, PTH, and calcium in relation to survival following prostate cancer

Similar Documents

Serum levels of vitamin D, parathyroid hormone and calcium in relation to survival following breast cancer

Vitamin D, PTH, and calcium and tumor aggressiveness in prostate cancer: a prospective nested case–control study

Vitamin D, PTH, and calcium and the risk of prostate cancer: a prospective nested case–control study

The epidemiology of vitamin D and cancer incidence and mortality: A review (United States)

Serum 25-OH vitamin D levels and risk of developing prostate cancer in older men

Adolescent dietary vitamin D and sun exposure in relation to benign breast disease

Coffee and tea consumption in relation to prostate cancer prognosis

Fat intake after prostate cancer diagnosis and mortality in the Physicians’ Health Study

Seasonal variation in expression of markers in the vitamin D pathway in prostate tissue

Vitamin D, PTH, and calcium in relation to survival following prostate cancer