NDLI: History of uterine leiomyomata and incidence of breast cancer

Content Provider	Springer Nature Link
Author	Wise, Lauren A. Radin, Rose G. Rosenberg, Lynn Adams Campbell, Lucile Palmer, Julie R.
Copyright Year	2015
Abstract	Uterine leiomyomata (UL), benign tumors of the myometrium, are influenced by sex steroid hormones. A history of UL diagnosis has been associated with a higher risk of uterine malignancies. The relation between UL and breast cancer, another hormonally responsive cancer, has not been studied.We investigated the association between self-reported physician-diagnosed UL and incidence of breast cancer in the Black Women’s Health Study, a prospective cohort study. We followed 57,747 participants without a history of breast cancer from 1995 to 2013. UL diagnoses were reported at baseline and biennially. Breast cancer was reported on biennial questionnaires and confirmed by pathology data from medical records or cancer registries. Cox regression was used to derive incidence rate ratios (IRRs) and 95 % confidence intervals (CI) and adjust for potential confounders.There were 2,276 incident cases of breast cancer (1,699 invasive, 394 in situ, and 183 unknown) during 879,672 person-years of follow-up. The multivariable IRR for the overall association between history of UL and breast cancer incidence was 0.99 (95 % CI 0.90–1.08), with similar results for ER + (IRR = 1.03) and ER − breast cancer (IRR = 1.05). IRRs for early diagnosis of UL (before age 30) were slightly above 1.0, with IRRs of 1.14 (95 % CI 0.99–1.31) for overall breast cancer, 1.14 (95 % CI 0.93–1.40) for ER + breast cancer, and 1.20 (95 % CI 0.89–1.61) for ER − breast cancer. IRRs for early diagnosis of UL were elevated for breast cancer diagnosed before 40 years of age (IRR = 1.39, 95 % CI 0.97–1.99) and premenopausal breast cancer (IRR = 1.26, 95 % CI 1.01–1.58). No consistent patterns in risk were observed across estrogen receptor subtypes, and IRRs did not differ appreciably within strata of BMI, female hormone use, mammography recency, or family history of breast cancer.The present study of US black women suggests that a history of UL diagnosis is unrelated to the incidence of breast cancer overall. The positive associations observed for early diagnosed UL with breast cancer before age 40 and with premenopausal breast cancer require confirmation in future studies.
Starting Page	1487
Ending Page	1493
Page Count	7
File Format	PDF
ISSN	09575243
Journal	Cancer Causes & Control
Volume Number	26
Issue Number	10
e-ISSN	15737225
Language	English
Publisher	Springer International Publishing
Publisher Date	2015-08-07
Publisher Place	Cham
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Black women Uterine leiomyoma Breast carcinoma Estrogen receptor Prospective studies Cancer Research Biomedicine general Oncology Public Health Epidemiology Hematology
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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