NDLI: Patients with prostate cancer are less likely to develop oesophageal adenocarcinoma: could androgens have a role in the aetiology of oesophageal adenocarcinoma?

Content Provider	Springer Nature Link
Author	Cooper, Sheldon C. Croft, Stacey Day, Rosie Thomson, Catherine S. Trudgill, Nigel J.
Copyright Year	2009
Abstract	Oesophageal adenocarcinoma (OAC) is more common in men. Androgens may therefore contribute to the pathogenesis of OAC. Prostate cancer (PC), an androgen sensitive tumor with a long natural history, may allow insights into this putative association. West Midlands Cancer Intelligence Unit data from 1977 to 2004 were examined to identify patients with a first malignant primary of PC. Patients were followed until diagnosis of a second primary cancer, death or end of the time period. Age- and period-adjusted standardized incidence ratios (SIR) were calculated as an estimate of the relative risk of a second malignant primary of the oesophagus. Between 1977 and 2004, 44,819 men within the West Midlands developed PC as a first primary malignancy. After exclusion for lack of follow-up, 38,627 men were eligible, providing 143,526 person years at risk for analysis. 86 second primary oesophageal cancers were observed, compared with 110 expected, resulting in an SIR of 0.78 (95% CI 0.62–0.96). There was a reduced risk of OAC 0.7 (0.5–0.95) but not of oesophageal squamous cell carcinoma (OSCC) 1.03 (0.69–1.47). The risk of developing OAC, but not OSCC, is lower than expected in patients with PC. A diagnosis of PC may be associated with aetiological factors that are negatively associated with OAC, or anti-androgen therapy may influence the development of OAC.
Starting Page	1363
Ending Page	1368
Page Count	6
File Format	PDF
ISSN	09575243
Journal	Cancer Causes & Control
Volume Number	20
Issue Number	8
e-ISSN	15737225
Language	English
Publisher	Springer Netherlands
Publisher Date	2009-05-20
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Oesophageal adenocarcinoma Oesophageal cancer Prostate cancer Androgens Hematology Epidemiology Public Health/Gesundheitswesen Oncology Biomedicine general Cancer Research
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Subjects with prostate cancer are less likely to develop esophageal cancer: analysis of SEER 9 registries database

Prostate cancer screening

Quantifying the role of PSA screening in the US prostate cancer mortality decline

Boron intake and prostate cancer risk

Male infertility and prostate cancer risk: a nested case–control study

Serum androgens and prostate cancer risk: results from the placebo arm of the Prostate Cancer Prevention Trial

The prognostic role of cancer-specific beliefs among prostate cancer survivors

Race, healthcare access and physician trust among prostate cancer patients

Common genetic polymorphisms of AURKA and prostate cancer risk

Patients with prostate cancer are less likely to develop oesophageal adenocarcinoma: could androgens have a role in the aetiology of oesophageal adenocarcinoma?

Similar Documents

Subjects with prostate cancer are less likely to develop esophageal cancer: analysis of SEER 9 registries database

Prostate cancer screening

Quantifying the role of PSA screening in the US prostate cancer mortality decline

Boron intake and prostate cancer risk

Male infertility and prostate cancer risk: a nested case–control study

Serum androgens and prostate cancer risk: results from the placebo arm of the Prostate Cancer Prevention Trial

The prognostic role of cancer-specific beliefs among prostate cancer survivors

Race, healthcare access and physician trust among prostate cancer patients

Common genetic polymorphisms of AURKA and prostate cancer risk

Patients with prostate cancer are less likely to develop oesophageal adenocarcinoma: could androgens have a role in the aetiology of oesophageal adenocarcinoma?