NDLI: Family history of various cancers and pancreatic cancer mortality in a large cohort

Content Provider	Springer Nature Link
Author	Jacobs, Eric J. Rodriguez, Carmen Newton, Christina C. Bain, Elizabeth B. Patel, Alpa V. Feigelson, Heather Spencer Thun, Michael J. Calle, Eugenia E.
Copyright Year	2009
Abstract	A family history of pancreatic cancer is associated with increased risk of pancreatic cancer, but uncertainty remains about the magnitude of this association, whether it varies by age or smoking and whether a family history of other cancers may also be associated with increased risk. We examined family history of 14 cancers and pancreatic cancer mortality among ~1.1 million men and women in Cancer Prevention Study-II (CPS-II). CPS-II participants completed a questionnaire at enrollment in 1982. During follow-up through 2006, there were 7,306 pancreatic cancer deaths. A family history of pancreatic cancer in a parent or sibling was associated with pancreatic cancer mortality [multivariable adjusted rate ratio (RR) = 1.66, 95% confidence interval (CI) 1.43–1.94]. This association was stronger among participants aged under 60 (RR = 2.89, 95% CI 1.67–5.02) than among participants aged 60 or older (RR = 1.61, 95% CI 1.37–1.88). Weaker associations were observed for family history of stomach cancer (RR = 1.23, 95% CI 1.11–1.37), liver cancer (RR = 1.25, 95% CI 1.10–1.43), and colorectal cancer (RR = 1.12, 95% CI 1.01–1.23). Results from this large prospective study indicate family history of pancreatic cancer is associated with a moderate increase in risk of pancreatic cancer, and also identify associations with the family history of certain other cancers which may be useful in generating hypotheses about shared risk factors.
Starting Page	1261
Ending Page	1269
Page Count	9
File Format	PDF
ISSN	09575243
Journal	Cancer Causes & Control
Volume Number	20
Issue Number	8
e-ISSN	15737225
Language	English
Publisher	Springer Netherlands
Publisher Date	2009-04-25
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Pancreatic cancer Family history Pancreatic neoplasms Cohort study Epidemiology Hematology Public Health/Gesundheitswesen Oncology Biomedicine general Cancer Research
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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