NDLI: Endogenous hormones, inflammation, and body size in premenopausal Mexican women: results from the Mexican Teachers’ Cohort (MTC, ESMaestras)

Content Provider	Springer Nature Link
Author	Rinaldi, Sabina Biessy, Carine Hernandez, Maria Lajous, Martin Ortiz Pazo, Eduardo Yunes, Elsa Lopez Ridaura, Ruy Torres Mejia, Gabriela Romieu, Isabelle
Copyright Year	2015
Abstract	Obesity is a major risk factor for several cancers, including female cancers. Endogenous hormones and inflammatory factors may mediate the association between anthropometric measures and cancer risk, although these associations have been studied mainly in Caucasians. The aim of the current study was to explore the association of circulating hormones, adipokines, and inflammatory factors with obesity and overweight in premenopausal Mexican women.We conducted a cross-sectional analysis of 504 premenopausal women from the large Mexican Teachers’ Cohort (MTC, ESMaestras) study to determine the association of insulin-like growth factor I (IGF-I), its major circulating binding protein (IGFBP-3), leptin, adiponectin, C-peptide, and C-reactive protein with comprehensive measures of body size. Biomarkers were measured by immunoassays. Multivariate regression analyses were performed to compare geometric mean biomarker concentrations with measured markers of body size and adiposity.Mean IGF-I and IGFBP-3 concentrations significantly increased with increasing height and leg length. Concentrations of IGF-I, adiponectin, and the IGF-I/IGFBP-3 ratio strongly decreased with increasing BMI, weight, waist and hip circumferences, waist-to-hip ratio (WHpR), and waist-to-height ratio (WHtR), while CRP, leptin, C-peptide concentrations, and the leptin/adiponectin ratio strongly increased. Adiponectin and the leptin/adiponectin ratio remained significantly related to measures of central adiposity (waist circumference, WHpR, and WHtR) after adjustment by body mass index.The results of our study suggest a strong relation between biomarkers and body size in this study population and suggest that different fat depots may have different metabolic properties.
Starting Page	475
Ending Page	486
Page Count	12
File Format	PDF
ISSN	09575243
Journal	Cancer Causes & Control
Volume Number	26
Issue Number	3
e-ISSN	15737225
Language	English
Publisher	Springer International Publishing
Publisher Date	2015-02-11
Publisher Place	Cham
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Endogenous hormones Inflammatory factors Body size Mexican premenopausal women Cross-sectional study Cancer Research Biomedicine general Oncology Public Health Epidemiology Hematology
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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