NDLI: Fasting insulin and endogenous hormones in relation to premenopausal breast density (Canada)

Content Provider	Springer Nature Link
Author	Borugian, Marilyn J. Spinelli, John J. Gordon, Paula B. Abanto, Zenaida Brooks Wilson, Angela Pollak, Michael N. Warren, Linda J. Hislop, T. Gregory Gallagher, Richard P.
Copyright Year	2014
Abstract	Mammographic breast density (BD) is associated with increased risk of breast cancer. This study asks which circulating metabolic and reproductive biomarkers are associated with BD, particularly dense breast area, in premenopausal women not taking exogenous hormones.In a cross-sectional study, 299 premenopausal women aged 40–49 completed questionnaires, provided a fasting blood sample, had height, weight, percentage body fat, waist and hip measurements taken, and attended a screening mammogram. Multivariate linear regression was used to calculate adjusted means for percentage BD, absolute dense and non-dense area, across categories of covariates, adjusted for day of menstrual cycle, age, parity, body mass index, percentage body fat, and ethnicity.Fasting insulin levels were inversely associated, and insulin-like growth factor-binding protein 1 levels directly associated with percentage BD, but lost statistical significance after multivariate adjustment. Sex hormone-binding globulin levels were directly associated with percentage BD, still significant after multivariate adjustment (p = 0.03). A significant inverse dose–response association was observed between progesterone levels and dense area (p < 0.01).Breast density in premenopausal women seems unrelated or inversely related to insulin resistance, levels of insulin-like growth factor 1 and its binding proteins, and levels of sex steroids; therefore, the mechanism by which radiodensity on a mammogram is related to breast cancer risk remains unclear.
Starting Page	385
Ending Page	394
Page Count	10
File Format	PDF
ISSN	09575243
Journal	Cancer Causes & Control
Volume Number	25
Issue Number	3
e-ISSN	15737225
Language	English
Publisher	Springer International Publishing
Publisher Date	2014-01-17
Publisher Place	Cham
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Mammographic breast density Insulin resistance Premenopausal Insulin-like growth factors Sex steroid hormones Breast cancer Cancer Research Biomedicine general Oncology Public Health Epidemiology Hematology
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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