NDLI: Vascular endothelial growth factor and breast cancer risk

Content Provider	Springer Nature Link
Author	Reeves, Katherine W. Ness, Roberta B. Stone, Roslyn A. Weissfeld, Joel L. Vogel, Victor G. Powers, Robert W. Modug, Francesmary Cauley, Jane A.
Copyright Year	2008
Abstract	Vascular endothelial growth factor (VEGF) is a key factor in angiogenesis and is important to carcinogenesis. Previous studies relating circulating levels of VEGF to breast cancer have been limited by small numbers of participants and lack of adjustment for confounders. We studied the association between serum VEGF and breast cancer in an unmatched case–control study of 407 pre- and postmenopausal women (n = 203 cases, n = 204 controls). Logistic regression was used to model the breast cancer risk as a function of natural log transformed VEGF levels adjusted for age, Gail score, education, physical activity, history of breastfeeding, serum testosterone, and hormone therapy (HT) use. The majority of the population was postmenopausal (67.6%) and the average age was 56 years; age and menopausal status were similar among cases and controls. Geometric mean VEGF levels were non-significantly higher in cases (321.4 pg/ml) than controls (291.4 pg/ml; p = 0.21). In a multivariable model, the odds of breast cancer was 37% higher for women with VEGF levels ≥314.2 pg/ml compared to those with levels below 314.2 pg/ml, albeit not significantly (p = 0.16). There was no interaction between VEGF and menopausal status (p = 0.52). In this case–control study, VEGF was not significantly associated with breast cancer risk in pre- and postmenopausal women.
Starting Page	375
Ending Page	386
Page Count	12
File Format	PDF
ISSN	09575243
Journal	Cancer Causes & Control
Volume Number	20
Issue Number	3
e-ISSN	15737225
Language	English
Publisher	Springer Netherlands
Publisher Date	2008-11-06
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Angiogenesis Breast neoplasms Premenopausal Postmenopausal Hematology Epidemiology Public Health/Gesundheitswesen Oncology Biomedicine general Cancer Research
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Birth size and breast cancer risk among young California-born women

Dietary patterns and the risk of postmenopausal breast cancer in a German case–control study

Vitamin D intake and breast cancer risk in postmenopausal women: the Iowa Women’s Health Study

Serum total cholesterol and the risk of breast cancer in postmenopausal Korean women

Association of Family History and Other risk factors with Breast Cancer Risk among Japanese Premenopausal and Postmenopausal Women

Association of serum phospholipid fatty acids with breast cancer risk among postmenopausal cigarette smokers

The contribution of postmenopausal hormone use cessation to the declining incidence of breast cancer

Serum calcium levels are elevated among women with untreated postmenopausal breast cancer

Complementary approaches to assessing risk factors for interval breast cancer

Vascular endothelial growth factor and breast cancer risk

Similar Documents

Birth size and breast cancer risk among young California-born women

Dietary patterns and the risk of postmenopausal breast cancer in a German case–control study

Vitamin D intake and breast cancer risk in postmenopausal women: the Iowa Women’s Health Study

Serum total cholesterol and the risk of breast cancer in postmenopausal Korean women

Association of Family History and Other risk factors with Breast Cancer Risk among Japanese Premenopausal and Postmenopausal Women

Association of serum phospholipid fatty acids with breast cancer risk among postmenopausal cigarette smokers

The contribution of postmenopausal hormone use cessation to the declining incidence of breast cancer

Serum calcium levels are elevated among women with untreated postmenopausal breast cancer

Complementary approaches to assessing risk factors for interval breast cancer

Vascular endothelial growth factor and breast cancer risk