NDLI: Cognitive impairment and cancer mortality: a biological or health care explanation?

Content Provider	Springer Nature Link
Author	Katsoulis, Michail Kyrozis, Andeas Trichopoulou, Antonia Bamia, Christina Trichopoulos, Dimitrios Lagiou, Pagona
Copyright Year	2014
Abstract	To examine whether the documented association of suboptimal cognitive function with total and cardiovascular (CVD) mortality also applies to cancer mortality and probe whether the explanation for this association is biomedical or health care related.In a subsample of 733 participants of the EPIC-Greece cohort from Athens and surrounding area, we assessed cognitive function at age 65 or older in the period 2004–2006, using the Mini-Mental State Examination (MMSE). Incidence of cancer, mortality from cancer and CVD, and overall mortality were ascertained through active follow-up for a median of 4 years after MMSE assessment using Cox proportional hazards models.A total of 86 participants died during follow-up. A 2-point decrease in MMSE score was associated with increase in overall (hazard ratio (HR) 1.26, 95 % confidence interval (CI) 1.11–1.43), CVD (HR 1.26, 95 % CI 1.02–1.56), and cancer (HR 1.32, 95 % CI 1.02–1.70) mortality. In contrast, there was no noticeable difference in cancer incidence associated with a 2-point decrease in MMSE score (HR 1.07, 95 % CI 0.79–1.45).Cognitive function appears to be inversely associated not only with CVD and overall, but also with cancer mortality. Although for CVD mortality there is a biomedical explanation invoking vascular mechanisms, for cancer mortality we may need to focus on socially conditioned factors, such as compromised ability to identify early signs and suboptimal compliance to treatment. Our hypothesis-generating results need to be confirmed in larger studies, as the issue is of major importance, since cognitive decline is not uncommon among the elderly.
Starting Page	1565
Ending Page	1570
Page Count	6
File Format	PDF
ISSN	09575243
Journal	Cancer Causes & Control
Volume Number	25
Issue Number	11
e-ISSN	15737225
Language	English
Publisher	Springer International Publishing
Publisher Date	2014-08-22
Publisher Place	Cham
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Cancer mortality Cognitive function Cognitive decline Cardiovascular mortality Cancer Research Biomedicine general Oncology Public Health Epidemiology Hematology
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Quantifying the role of PSA screening in the US prostate cancer mortality decline

Prostate cancer mortality and birth or adult residence in the southern United States

Metformin and prostate cancer mortality: a meta-analysis

Regional variations in German mesothelioma mortality rates: 2000–2010

Ambient air pollution and brain cancer mortality

Statins and breast cancer stage and mortality in the Women’s Health Initiative

Diet impacts mortality from cancer: results from the multiethnic cohort study

Serum uric acid levels and cancer mortality risk among males in a large general population-based cohort study

Fat intake after prostate cancer diagnosis and mortality in the Physicians’ Health Study

Cognitive impairment and cancer mortality: a biological or health care explanation?

Similar Documents

Quantifying the role of PSA screening in the US prostate cancer mortality decline

Prostate cancer mortality and birth or adult residence in the southern United States

Metformin and prostate cancer mortality: a meta-analysis

Regional variations in German mesothelioma mortality rates: 2000–2010

Ambient air pollution and brain cancer mortality

Statins and breast cancer stage and mortality in the Women’s Health Initiative

Diet impacts mortality from cancer: results from the multiethnic cohort study

Serum uric acid levels and cancer mortality risk among males in a large general population-based cohort study

Fat intake after prostate cancer diagnosis and mortality in the Physicians’ Health Study

Cognitive impairment and cancer mortality: a biological or health care explanation?