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| Content Provider | Springer Nature Link |
|---|---|
| Author | Zhang, Yuqing Coogan, Patricia F. Palmer, Julie R. Strom, Brian L. Rosenberg, Lynn |
| Copyright Year | 2009 |
| Abstract | Findings from several previous studies that have assessed the relation of reproductive factors and female hormone use to the risk of pancreatic cancer are inconclusive. The authors examined the association between reproductive factors and the use of oral contraceptives and postmenopausal hormone therapy to the risk of pancreatic cancer among 284 patients with pancreatic cancer and 1,096 controls using data from the hospital-based Case–Control Surveillance Study. Older age at first pregnancy and long-duration oral contraceptive use were associated with an increased risk of pancreatic cancer: the odds ratio was 2.0 (95% CI: 1.1–3.3) for first birth at age 30 or older compared with before age 20 (p for trend = 0.042) and 2.0 (95% CI: 1.0–4.0) for ten or more years of use of oral contraceptive use relative to no-use (p for trend < 0.01). Risk of pancreatic cancer risk was not associated with postmenopausal female hormone use. The findings suggest that increased exposure to estrogen during the reproductive years may play a role in the development of pancreatic cancer in women. Further studies are needed to confirm the findings. |
| Starting Page | 473 |
| Ending Page | 478 |
| Page Count | 6 |
| File Format | |
| ISSN | 09575243 |
| Journal | Cancer Causes & Control |
| Volume Number | 21 |
| Issue Number | 3 |
| e-ISSN | 15737225 |
| Language | English |
| Publisher | Springer Netherlands |
| Publisher Date | 2009-11-26 |
| Publisher Place | Dordrecht |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Pancreatic neoplasm Oral contraceptive Reproductive factors Case–control studies Hematology Epidemiology Public Health/Gesundheitswesen Oncology Biomedicine general Cancer Research |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Oncology |
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