NDLI: Vascular morphology differentiates prostate cancer mortality risk among men with higher Gleason grade

Content Provider	Springer Nature Link
Author	Yang, Meng Zu, Ke Mucci, Lorelei A. Rider, Jennifer R. Fiorenti, Michelangelo Clinton, Steven K. Loda, Massimo Stampfer, Meir J. Giovannucci, Edward
Copyright Year	2016
Abstract	Higher Gleason grade is associated with prostate cancer mortality; however, there is significant heterogeneity in this association. We evaluated whether vessel morphology, a biomarker of angiogenesis, aided in distinguishing mortality risks among men with high Gleason grading.We characterized vessel morphology (area and irregularity) among 511 patients diagnosed with prostate cancer during 1986 to 2000, re-reviewed Gleason grade, and followed men through 2012. Men were grouped according to integrated vessel lumen irregularity and vessel area across Gleason grade. The more angiogenic group was identified as those with more irregular vessel lumen and smaller vessel area. Crude rates (95 % confidence intervals) and survival probability were estimated across Gleason grade and vessel morphology.During a median 14-year follow-up, 62 men developed bone metastases or died of prostate cancer. Lethality rates were uniformly low within Gleason grade categories 6 and 7(3 + 4), regardless of vessel morphology. However, among men with Gleason grades of 7(4 + 3) or 8–10, the more angiogenic group was associated with fourfold higher risk of lethal outcomes compared to those with less angiogenic potential. Ten-year survival probability ranged from 95 to 74 % according to the extent of vessel morphology (p < 0.0001, log-rank test).Vessel morphology may aid Gleason grading in predicting prostate cancer mortality risks among men diagnosed with high-grade Gleason cancers.
Starting Page	1043
Ending Page	1047
Page Count	5
File Format	PDF
ISSN	09575243
Journal	Cancer Causes & Control
Volume Number	27
Issue Number	8
e-ISSN	15737225
Language	English
Publisher	Springer International Publishing
Publisher Date	2016-07-05
Publisher Place	Cham
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Vessel morphology Angiogenesis Gleason grade Prostate cancer mortality Cancer Research Biomedicine general Oncology Public Health Epidemiology Hematology
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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