NDLI: Ipsilateral Alteration of Resting State Activity Suggests That Cortical Dysfunction Contributes to the Pathogenesis of Cluster Headache

Content Provider	Springer Nature Link
Author	Faragó, Péter Szabó, Nikoletta Tóth, Eszter Tuka, Bernadett Király, András Csete, Gergő Párdutz, Árpád Szok, Délia Tajti, Jás Ertsey, Csaba Vécsei, László Kincses, Zsigmond Tamás
Copyright Year	2016
Abstract	The pathomechanism of cluster headache (CH) is not entirely understood, but central and peripheral components were suggested. A recent report showed that transcranial magnetic stimulation measured cortical excitability was increased in the hemisphere ipsilalteral to the pain. In the current study we set out to investigate the amplitude of resting brain fMRI activity to find signatures of the increased excitability. High resolution T1 weighted and resting state functional MRI images were acquired from seventeen patients with CH in pain free period and from twenty-six healthy volunteers. Patients’ data were normalized (e.g. inverted along the midsagittal axis) according to the headache side. Independent component analysis and a modified dual regression approach were used to reveal the differences between the resting state networks. Furthermore, the timecourses were decomposed into five frequency bands by discrete wavelet decomposition and were also re-regressed to the original data to reveal frequency specific resting activity maps. Two of the identified resting state networks showed alterations in CH. When the data were inverted to have patients’ headaches on the left, the ipsilateral attention network showed increased connectivity in 0.08–0.04 Hz frequency band in the in CH group. In the same dataset, cerebellar network showed higher functional connectivity in 0.02–0.01 Hz range in the ipsilateral cerebellum. When the data of patients having headache on the left were inverted to the right, similar increased signal was found in the ipsilateral attention network in 0.08–0.04 Hz band. The cerebellar network showed increased connectivity in the cerebellum in 0.02–0.01 Hz band in patients. The Fourier analysis of these area revealed increased power in CH at all cases. Our results showed alterations of brain functional networks in CH. The alterations of resting state activity were found in the hemisphere ipsilateral to the pain, signifying the altered cortical processing in the pathomechanism of CH.
Starting Page	281
Ending Page	289
Page Count	9
File Format	PDF
ISSN	08960267
Journal	Brain Topography
Volume Number	30
Issue Number	2
e-ISSN	15736792
Language	English
Publisher	Springer US
Publisher Date	2016-11-04
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Cluster headache MRI Resting state networks Dual regression Frequency analysis Neurosciences Psychiatry Neurology
Content Type	Text
Resource Type	Article
Subject	Neurology Anatomy Radiology, Nuclear Medicine and Imaging Neurology (clinical) Radiological and Ultrasound Technology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Low-Dimensional Dynamics of Resting-State Cortical Activity

Electrophysiological Correlation Patterns of Resting State Networks in Single Subjects: A Combined EEG–fMRI Study

Resting State fMRI Demonstrates a Disturbance of the Cerebello-Cortical Circuit in Essential Tremor

Low-Frequency MEG Activity and MRI Evaluation in Parkinson's Disease

Detecting Functional Connectivity in fMRI Using PCA and Regression Analysis

Data from: Task-related effective connectivity reveals that the cortical rich club gates cortex-wide communication (Dataset)

Association Between Resting-State Microstates and Ratings on the Amsterdam Resting-State Questionnaire

Wiener Filter-Magnetoencephalography of Visual Cortical Activity

Brain regions involved in fractional amplitude of low-frequency fluctuation in cluster headache patients: a resting-state functional MRI study

Ipsilateral Alteration of Resting State Activity Suggests That Cortical Dysfunction Contributes to the Pathogenesis of Cluster Headache

Similar Documents

Low-Dimensional Dynamics of Resting-State Cortical Activity

Electrophysiological Correlation Patterns of Resting State Networks in Single Subjects: A Combined EEG–fMRI Study

Resting State fMRI Demonstrates a Disturbance of the Cerebello-Cortical Circuit in Essential Tremor

Low-Frequency MEG Activity and MRI Evaluation in Parkinson's Disease

Detecting Functional Connectivity in fMRI Using PCA and Regression Analysis

Data from: Task-related effective connectivity reveals that the cortical rich club gates cortex-wide communication (Dataset)

Association Between Resting-State Microstates and Ratings on the Amsterdam Resting-State Questionnaire

Wiener Filter-Magnetoencephalography of Visual Cortical Activity

Brain regions involved in fractional amplitude of low-frequency fluctuation in cluster headache patients: a resting-state functional MRI study

Ipsilateral Alteration of Resting State Activity Suggests That Cortical Dysfunction Contributes to the Pathogenesis of Cluster Headache