NDLI: Beyond the Arcuate Fasciculus: Damage to Ventral and Dorsal Language Pathways in Aphasia

Content Provider	Springer Nature Link
Author	Yang, Mi Li, Yibo Li, Jiao Yao, Dezhong Liao, Wei Chen, Huafu
Copyright Year	2016
Abstract	Previous regional-based diffusion tensor imaging (DTI) studies focused on impairment of the arcuate fasciculus in aphasia; little is known about the extent to which aphasia severity is affected by damage to both ventral and dorsal language white matter (WM) pathways. To understand whether disconnection of these pathways contributes to clinical symptoms, we assessed the relationship between the alterations of WM integrity and clinical characteristics in acute aphasia after stroke. Eighteen patients with acute aphasia and age-, gender-, and education-matched healthy controls underwent language assessment and DTI scanning. The whole brain unbiased tract-based spatial statistics method was employed to quantitate WM integrity (fractional anisotropy) for both groups. Linear correlation analyses were performed to evaluate the relationship between WM integrity and clinical features. The aphasic patients showed decreased WM integrity in the left inferior fronto-occipital fasciculus/inferior longitudinal fasciculus (IFOF/ILF) and the left uncinate fasciculus, which represents components of ventral language pathway, and the left superior longitudinal fasciculus (SLF), which relates to dorsal language pathway. In addition, WM integrity of the left IFOF and SLF showed a positive correlation with aphasia quotient, performance quotient, and cortical quotient, respectively. These findings suggested that impaired WM integrity in both language pathways not only contributed to language performance, but also to general cognitive status. We suggest that aphasia involves a breakdown of multiple connections of dorsal and ventral streams that directly contributes to language deficits. Damage to these dual-streams may serve as a neuromarker for aphasias after stroke.
Starting Page	249
Ending Page	256
Page Count	8
File Format	PDF
ISSN	08960267
Journal	Brain Topography
Volume Number	30
Issue Number	2
e-ISSN	15736792
Language	English
Publisher	Springer US
Publisher Date	2016-06-20
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Aphasia Dorsal stream Tract-based spatial statistics Ventral stream White matter integrity Neurosciences Psychiatry Neurology
Content Type	Text
Resource Type	Article
Subject	Neurology Anatomy Radiology, Nuclear Medicine and Imaging Neurology (clinical) Radiological and Ultrasound Technology

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