NDLI: Novel scalable and monolithically integrated extracorporeal gas exchange device

Content Provider	Springer Nature Link
Author	Rieper, Tina Müller, Claas Reinecke, Holger
Copyright Year	2015
Abstract	A novel extracorporeal gas exchange device (EGED) is developed, implemented and characterized. The aim hereby is to overcome drawbacks of state-of-the-art devices and of state-of-science approaches, like their labor intensive fabrication and their low volume density of the gas exchange area, respectively. As a consequence of the stacked setup of alternating layers of the blood compartment and the ventilation gas compartment, the developed EGED allows for double sided gas exchange. Furthermore, it enables an adaption to the diversity of medical requirements by scaling the amount of layers. The developed fabrication chain is used to fabricate leakage-free evaluation models and allows for a transition to automated fabrication. The EGED is completely fabricated in polydimethylsiloxane (PDMS) and features diffusion membranes, which are separating the compartments, with a mean thickness of 90 μm. With the evaluation models and oxygen as ventilation gas an oxygen transfer of 60 ml/lblood (25 ml/(min m2)) and a carbon dioxide transfer of 70 ml/lblood (30 ml/(min m2)) are achieved. The linear scalability of the concept as well as the functionality of the EGED with air as ventilation gas is shown.
Starting Page	1
Ending Page	10
Page Count	10
File Format	PDF
ISSN	13872176
Journal	Biomedical Microdevices
Volume Number	17
Issue Number	5
e-ISSN	15728781
Language	English
Publisher	Springer US
Publisher Date	2015-08-07
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Extracorporeal gas exchange Silicone rubber processing Gas transfer simulation Large area bonding of microstructured PDMS sheets Microstructured, thin PDMS sheets Biomedical Engineering Biophysics and Biological Physics Nanotechnology Engineering Fluid Dynamics
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Molecular Biology Biomedical Engineering

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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