NDLI: Piezo-actuated parallel mechanism for biological cell release at high speed

Content Provider	Springer Nature Link
Author	Avci, Ebubekir Hattori, Takayuki Kamiyama, Kazuto Kojima, Masaru Horade, Mitsuhiro Mae, Yasushi Arai, Tatsuo
Copyright Year	2015
Abstract	In this paper, a dynamic releasing approach is proposed for high-speed biological cell manipulation. A compact parallel mechanism for grasping and releasing microobjects is used to generate controllable vibration to overcome the strong adhesion forces between the end effector and the manipulated object. To reach the required acceleration of the end effector, which is necessary for the detachment of the target object by overcoming adhesion forces, vibration in the end effector is generated by applying sinusoidal voltage to the PZT actuator of the parallel mechanism. For the necessary acceleration, we focus on the possible range of the frequency of the PZT-actuator-induced vibration, while minimizing the amplitude of the vibration (14 nm) to achieve precise positioning. The effect of the air and liquid environments on the required vibration frequency for successful release is investigated. For the first time, release results of microbeads and biological cells are compared. Release of the biological cells with 100 % success rate suggests that the proposed active release method is an appropriate solution for adhered biological cells during the release task.
Starting Page	1
Ending Page	10
Page Count	10
File Format	PDF
ISSN	13872176
Journal	Biomedical Microdevices
Volume Number	17
Issue Number	5
e-ISSN	15728781
Language	English
Publisher	Springer US
Publisher Date	2015-09-07
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Cell handling Micro-scale release Controlled vibration Micro-manipulation Piezo actuator Biomedical Engineering Biophysics and Biological Physics Nanotechnology Engineering Fluid Dynamics
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Molecular Biology Biomedical Engineering

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