NDLI: Continuous high-throughput phosphopeptide enrichment using microfluidic channels modified with aligned ZnO/TiO2 nanorod arrays

Content Provider	Springer Nature Link
Author	He, Zhongyuan Zhang, Qinghong Wang, Hongzhi Li, Yaogang
Copyright Year	2011
Abstract	A capillary microchannel (CM) containing TiO2-coated ZnO nanorod arrays was applied as a novel microfluidic device to selectively bind and enrich phosphopeptides. The device was prepared by pumping a TiO2 sol into a CM containing preformed ZnO nanorod arrays. Different thicknesses of the TiO2 coating were obtained by controlling the flow duration of TiO2 sol. The modified CM achieved uninterrupted high-throughput introduction, capture and enrichment of phosphopeptides using continuous-flow operation. The microfluidic device based on the modified CM showed great selectivity, sensitivity and durability for the enrichment of phosphopeptides from tryptic protein digests. These results suggest that microfluidic chips employing this strategy can be used for rapid and high-throughput enrichment of phosphopeptides from complex mixtures.
Starting Page	865
Ending Page	875
Page Count	11
File Format	PDF
ISSN	13872176
Journal	Biomedical Microdevices
Volume Number	13
Issue Number	5
e-ISSN	15728781
Language	English
Publisher	Springer US
Publisher Date	2011-06-23
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Microfluidic device TiO2/ZnO nanorod arrays Phosphopeptide enrichment Continuous-flow High-throughput Nanobiotechnology Biophysics and Biological Physics Nanotechnology Biomedical Engineering Engineering Fluid Dynamics
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Molecular Biology Biomedical Engineering

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