NDLI: Pure mitochondrial DNA does not activate human neutrophils in vitro

Content Provider	Springer Nature Link
Author	Prikhodko, A. S. Shabav, A. K. Zivkina, L. A. Popova, E. N. Aznauryan, M. A. Lanina, N. O. Vitushkina, M. V. Zivkin, R. A.
Copyright Year	2015
Abstract	Excessive activation of the innate immune system often leads to fatal consequences and can be considered as one of the phenoptotic events. After traumatic injury, various components of mitochondria are released into the circulation and stimulate myeloid cells of the innate immunity. Presumably, mitochondrial DNA (mtDNA) might activate immune cells (Zhang, Q., et al. (2010) Nature, 464, 104–107). In the present study, we investigated the role of mtDNA as a direct activator of human neutrophils, as well as a prognostic marker in patients with severe trauma. Quantitative determination of mtDNA in the plasma of these patients revealed its significant increase (p < 0.02) in the group of survivors compared to nonsurvivors. Highly purified mtDNA was not able to induce activation of human neutrophils, thus possibly indicating the existence of additional factor(s) ensuring the recognition of mtDNA as a damage-associated molecular pattern.
Starting Page	629
Ending Page	635
Page Count	7
File Format	PDF
ISSN	00062979
Journal	Biochemistry (Moscow)
Volume Number	80
Issue Number	5
e-ISSN	16083040
Language	English
Publisher	Pleiades Publishing
Publisher Date	2015-05-10
Publisher Place	Moscow
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	trauma extracellular DNA mitochondrial DNA neutrophil activation damage-associated molecular patterns (DAMPs) Biochemistry Bioorganic Chemistry Microbiology Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Biochemistry Biophysics Geriatrics and Gerontology

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