NDLI: Manganese elevates manganese superoxide dismutase protein level through protein kinase C and protein tyrosine kinase

Please wait, while we are loading the content...

The zinc transporter ZNT3 co-localizes with insulin in INS-1E pancreatic beta cells and influences cell survival, insulin secretion capacity, and ZNT8 expression

Simulating hypoxia-induced acidic environment in cancer cells facilitates mobilization and redox-cycling of genomic copper by daidzein leading to pro-oxidant cell death: implications for the sensitization of resistant hypoxic cancer cells to therapeutic challenges

Bismuth(III) deferiprone effectively inhibits growth of Desulfovibrio desulfuricans ATCC 27774

Polysaccharide-based silver nanoparticles synthesized by Klebsiella oxytoca DSM 29614 cause DNA fragmentation in E. coli cells

HmuS and HmuQ of Ensifer/Sinorhizobium meliloti degrade heme in vitro and participate in heme metabolism in vivo

Functional analysis of two genes coding for distinct cation diffusion facilitators of the ectomycorrhizal Zn-accumulating fungus Russula atropurpurea

BioMetals : Volume 29, Issue 1, February 2016

BioMetals : Volume 28

BioMetals : Volume 27

BioMetals : Volume 26

BioMetals : Volume 25

BioMetals : Volume 24

BioMetals : Volume 23

BioMetals : Volume 22

BioMetals : Volume 21

BioMetals : Volume 20

BioMetals : Volume 19

BioMetals : Volume 18

BioMetals : Volume 17

BioMetals : Volume 16

BioMetals : Volume 15

BioMetals : Volume 14

BioMetals : Volume 13

BioMetals : Volume 12

BioMetals : Volume 11

BioMetals : Volume 10

Manganese elevates manganese superoxide dismutase protein level through protein kinase C and protein tyrosine kinase

Content Provider	Springer Nature Link
Author	Li, Sufen Lu, Lin Liao, Xiudong Gao, Tianquan Wang, Funing Zhang, Liyang Xi, Lin Liu, Songbai Luo, Xugang
Copyright Year	2016
Abstract	Three experiments were conducted to investigate the effects of inorganic and organic Mn sources on MnSOD mRNA, protein and enzymatic activity and the possible signal pathways. The primary broiler myocardial cells were treated with MnCl2 (I) or one of organic chelates of Mn and amino acids with weak, moderate (M) or strong (S) chelation strength for 12 and 48 h. Cells were preincubated with superoxide radical anions scavenger N-acetylcysteine (NAC) or specific inhibitors for MAPKs and protein tyrosine kinase (PTK) or protein kinase C (PKC) for 30 min before treatments of I and M. The MnSOD mRNA, protein and enzymatic activity, phosphorylated MAPKs or protein kinases activations were examined. The results showed that additions of Mn increased (P < 0.05) MnSOD mRNA levels and M was more effective than I. Additions of Mn elevated (P < 0.05) MnSOD protein levels and enzymatic activities, and no differences were found among I and M. Addition of NAC did not decrease (P > 0.05) Mn-induced MnSOD mRNA and protein levels. None of the three MAPKs was phosphorylated (P > 0.05) by Mn. Additions of Mn decreased (P < 0.05) the PTK activities and increased (P < 0.05) the membrane PKC contents. Inhibitors for PTK or PKC decreased (P < 0.05) Mn-induced MnSOD protein levels. The results suggested that Mn-induced MnSOD mRNA and protein expressions be not related with NAC, and MAPK pathways might not involve in Mn-induced MnSOD mRNA expression. PKC and PTK mediated the Mn-induced MnSOD protein expression.
Starting Page	265
Ending Page	274
Page Count	10
File Format	PDF
ISSN	09660844
Journal	BioMetals
Volume Number	29
Issue Number	2
e-ISSN	15728773
Language	English
Publisher	Springer Netherlands
Publisher Date	2016-02-08
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Manganese Manganese superoxide dismutase Mitogen-activated protein kinases Protein kinase C Protein tyrosine kinase broiler myocardial cell Biochemistry Pharmacology/Toxicology Microbiology Cell Biology Plant Physiology Medicine/Public Health
Content Type	Text
Resource Type	Article
Subject	Metals and Alloys Biochemistry, Genetics and Molecular Biology Biomaterials Agricultural and Biological Sciences

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Activation of the p38 and p42/p44 mitogen-activated protein kinase families by the histamine $H_{1}$ receptor in $DDT_{1}MF-2$ cells

Cancer Cell-derived Exosomes Induce Mitogen-activated Protein Kinase-dependent Monocyte Survival by Transport of Functional Receptor Tyrosine Kinases

Protein kinase C/mitogen-activated protein kinase signaling in keratinocyte differentiation control.

Benzydamine inhibits monocyte migration and MAPK activation induced by chemotactic agonists.

Breast Cancer-derived Factors Stimulate Osteoclastogenesis through the $Ca^{2+}/Protein$ Kinase C and Transforming Growth Factor-β/MAPK Signaling Pathways

Manganese-Mediated Decrease in Levels of c-RET and Tyrosine Hydroxylase Expression In Vitro

A docking site in MKK4 mediates high affinity binding to JNK MAPKs and competes with similar docking sites in JNK substrates.

Role of c-Src Tyrosine Kinase in G Protein-coupled Receptorand Gβγ Subunit-mediated Activation of Mitogen-activated Protein Kinases

Activation of Stress-activated Protein Kinases/c-Jun N-terminal Protein Kinases (SAPKs/JNKs) by a Novel Mitogen-activated Protein Kinase Kinase (MKK7)

Manganese elevates manganese superoxide dismutase protein level through protein kinase C and protein tyrosine kinase

Similar Documents

Activation of the p38 and p42/p44 mitogen-activated protein kinase families by the histamine $H_{1}$ receptor in $DDT_{1}MF-2$ cells

Cancer Cell-derived Exosomes Induce Mitogen-activated Protein Kinase-dependent Monocyte Survival by Transport of Functional Receptor Tyrosine Kinases

Protein kinase C/mitogen-activated protein kinase signaling in keratinocyte differentiation control.

Benzydamine inhibits monocyte migration and MAPK activation induced by chemotactic agonists.

Breast Cancer-derived Factors Stimulate Osteoclastogenesis through the $Ca^{2+}/Protein$ Kinase C and Transforming Growth Factor-β/MAPK Signaling Pathways

Manganese-Mediated Decrease in Levels of c-RET and Tyrosine Hydroxylase Expression In Vitro

A docking site in MKK4 mediates high affinity binding to JNK MAPKs and competes with similar docking sites in JNK substrates.

Role of c-Src Tyrosine Kinase in G Protein-coupled Receptorand Gβγ Subunit-mediated Activation of Mitogen-activated Protein Kinases

Activation of Stress-activated Protein Kinases/c-Jun N-terminal Protein Kinases (SAPKs/JNKs) by a Novel Mitogen-activated Protein Kinase Kinase (MKK7)

Manganese elevates manganese superoxide dismutase protein level through protein kinase C and protein tyrosine kinase