NDLI: Structural Changes in the Promoter Region Mediate Transvection at the sn-Glycerol-3-Phosphate Dehydrogenase Gene of Drosophila melanogaster

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Structural Changes in the Promoter Region Mediate Transvection at the sn-Glycerol-3-Phosphate Dehydrogenase Gene of Drosophila melanogaster

Content Provider	Springer Nature Link
Author	Gibson, J. B. Reed, D. S. Bartoszewski, S. Wilks, A. V.
Copyright Year	1999
Abstract	Trans effects at the sn-glycerol-3-phosphatedehydrogenase locus (Gpdh) of Drosophilamelanogaster give rise to an increase in GPDHactivity and mRNA from the wild-type allele inheterozygotes with some low-activity alleles. Either the low-activityalleles that induce the effect have a defectiveP-element inserted between the promoter and a downstreamintronic enhancer element or the promoter region is deleted. The trans effect is pairing dependent,characteristic of transvection at some other loci. Thedefective P-elements that mediate transvection arelocated between the promoter and at least up to 6 bp downstream of the transcription startsite. Transvection at Gpdh appears similar to the“enhancer action in trans” mode at theyellow locus.
Starting Page	301
Ending Page	315
Page Count	15
File Format	PDF
ISSN	00062928
Journal	Biochemical Genetics
Volume Number	37
Issue Number	9-10
e-ISSN	15734927
Language	English
Publisher	Kluwer Academic Publishers-Plenum Publishers
Publisher Date	1999-01-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Human Genetics Medical Microbiology Biochemistry Zoology
Content Type	Text
Resource Type	Article
Subject	Genetics Medicine Biochemistry Molecular Biology Ecology, Evolution, Behavior and Systematics

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