NDLI: The dietary restriction effect in C. elegans and humans: is the worm a one-millimeter human?

Content Provider	Springer Nature Link
Author	Braeckman, Bart P. Demetrius, Lloyd Vanfleteren, Jacques R.
Copyright Year	2006
Abstract	Dietary restriction (DR) lengthens life span in wide range of vertebrate and invertebrate species. The molecular mechanism by which DR increases life span and the universality of its effects (and hence its applicability to humans) are currently debated in gerontology. This article addresses these two problems from both an experimental perspective, using the nematode C. elegans as a model system, and a theoretical viewpoint, by appealing to recent mechanistic and evolutionary models of aging. Molecular mechanisms of aging are analysed by contrasting the rate of living/oxidative stress hypothesis with the metabolic stability/longevity hypothesis, a new model of aging which postulates that the robustness of metabolic networks, rather than metabolic rate per se, is the major determinant of aging. Studies of food-restricted worms are shown to be consistent with the metabolic stability/longevity hypothesis. The universality of the effects of DR is addressed in terms of directionality theory, an evolutionary model, which is based on the analytical fact that the robustness or the stability of demographic networks determines Darwinian fitness. Directionality theory, in conjunction with the metabolic stability hypothesis, predicts that DR will have negligible effects on equilibrium species (late age of sexual maturity, small size of progeny sets and broad reproductive span) and large effects on opportunistic species (early age of maturity, large size of progeny sets, narrow reproductive span). Empirical studies using C. elegans (an opportunistic species) and computational studies on human populations (an equilibrium species) are shown to be consistent with these predictions.
Starting Page	127
Ending Page	133
Page Count	7
File Format	PDF
ISSN	13895729
Journal	Biogerontology
Volume Number	7
Issue Number	3
e-ISSN	15736768
Language	English
Publisher	Kluwer Academic Publishers
Publisher Date	2006-05-27
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Dietary restriction Longevity Metabolic stability Caenorhabditis elegans Human Developmental Biology Cell Biology Geriatrics/Gerontology
Content Type	Text
Resource Type	Article
Subject	Aging Gerontology Geriatrics and Gerontology

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