NDLI: At the Heart of Aging: is it Metabolic Rate or Stability?

Content Provider	Springer Nature Link
Author	Olshansky, S. Jay Rattan, Suresh I. S.
Copyright Year	2005
Abstract	Foundational changes in science are rare, but in the field of biogerontology there is a new theory of aging that may shake things up. The conventional wisdom about duration of life is based on an old idea known as the “rate of living” theory, which suggests that aging is caused by the loss of some vital substance. The modern version of this theory is that duration of life is influenced by the relative speed of a species’ resting metabolism. However, empirical evidence does not consistently support this hypothesis. In an article published recently by mathematician/biologist Lloyd Demetrius, it is suggested that the most important factor involved in duration of life is not metabolic rate or oxidative stress, but metabolic stability. If Demetrius is correct, his theory will have important implications for intervention research. For example, if the metabolic rate/oxidative stress theory is correct, efforts to intervene in the aging process should be directed at finding ways to reduce metabolic rate, lessen the production of reactive oxygen species (ROS), improve antioxidant defenses, or increase the quantity of antioxidants. If the metabolic stability hypothesis is correct, efforts to intervene in the aging process should be directed at finding ways to increase the stability of the steady state values of ROS, increase the robustness of metabolic networks, or improve the stability of antioxidant enzymes. For now there is reason to believe that Demetrius’ theory deserves further consideration – whether it meets the test of a paradigm shift has yet to be determined.
Starting Page	291
Ending Page	295
Page Count	5
File Format	PDF
ISSN	13895729
Journal	Biogerontology
Volume Number	6
Issue Number	4
e-ISSN	15736768
Language	English
Publisher	Kluwer Academic Publishers
Publisher Date	2005-01-01
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	anti-aging caloric restriction longevity metabolism rate of living Geriatrics/Gerontology Cell Biology Developmental Biology
Content Type	Text
Resource Type	Article
Subject	Aging Gerontology Geriatrics and Gerontology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Caloric restriction and human longevity: what can we learn from the Okinawans?

Caloric Restriction Increases Longevity Substantially only When the Reaction Norm is Steep

Health span extension by later-life caloric or dietary restriction: a view based on rodent studies

Effects of Aging and Anti-Aging Caloric Restrictions on Carbonyl and Heat Shock Protein Levels and Expression

Effects of caloric restriction are species-specific

The dietary restriction effect in C. elegans and humans: is the worm a one-millimeter human?

Is rate of skin wound healing associated with aging or longevity phenotype?

A mathematical model that accounts for the effects of caloric restriction on body weight and longevity

Mitochondrial metabolic failure in telomere attrition-provoked aging of bone marrow mesenchymal stem cells

At the Heart of Aging: is it Metabolic Rate or Stability?

Similar Documents

Caloric restriction and human longevity: what can we learn from the Okinawans?

Caloric Restriction Increases Longevity Substantially only When the Reaction Norm is Steep

Health span extension by later-life caloric or dietary restriction: a view based on rodent studies

Effects of Aging and Anti-Aging Caloric Restrictions on Carbonyl and Heat Shock Protein Levels and Expression

Effects of caloric restriction are species-specific

The dietary restriction effect in C. elegans and humans: is the worm a one-millimeter human?

Is rate of skin wound healing associated with aging or longevity phenotype?

A mathematical model that accounts for the effects of caloric restriction on body weight and longevity

Mitochondrial metabolic failure in telomere attrition-provoked aging of bone marrow mesenchymal stem cells

At the Heart of Aging: is it Metabolic Rate or Stability?