NDLI: Mitochondrial alterations, cellular response to oxidative stress and defective degradation of proteins in aging

Content Provider	Springer Nature Link
Author	Lee, Hsin Chen Wei, Yau Huei
Copyright Year	2001
Abstract	Respiratory function decline and increase ofoxidative stress in mitochondria have beenproposed as important contributors to humanaging. A wide spectrum of alterations in agedindividuals and senescent cells are similar andare correlated to cellular response tosublethal dose of oxidative stress. Thesealterations and responses include: (1) declinein mitochondrial respiratory function; (2)increase in the rate of production of reactiveoxygen species (ROS); (3) accumulation ofmitochondrial DNA (mtDNA) mutations; (4)increase in the levels of oxidative damage toDNA, protein, and lipids; and (5) decrease inthe capacities of degradation of oxidativelydamaged proteins and other macromolecules. Responses to oxidative stress and theirsubsequent interactions in tissues result inthe deleterious effect of ROS on the cellularfunction, which culminate in aging anddegenerative diseases. In this review, wefocus on the roles that ROS play in age-relatedoxidative damage to mtDNA and proteins andoxidative stress responses at the molecular andcellular levels. The alterations of geneexpression profiles elicited by oxidativestress in aging animals are discussed. Wesuggest that the increase in mitochondrialproduction of ROS and decline in the cellularcapacity to cope with oxidative stress andsubsequent accumulation of mtDNA mutations andoxidized proteins play an important role in theaging process.
Starting Page	231
Ending Page	244
Page Count	14
File Format	PDF
ISSN	13895729
Journal	Biogerontology
Volume Number	2
Issue Number	4
e-ISSN	15736768
Language	English
Publisher	Kluwer Academic Publishers
Publisher Date	2001-01-01
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Geriatrics/Gerontology Proteomics Cell Biology Developmental Biology Animal Anatomy / Morphology / Histology
Content Type	Text
Resource Type	Article
Subject	Aging Gerontology Geriatrics and Gerontology

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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Contents Volume 2

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Mitochondrial alterations, cellular response to oxidative stress and defective degradation of proteins in aging

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Contents Volume 2

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Mitochondrial alterations, cellular response to oxidative stress and defective degradation of proteins in aging