NDLI: Dose-dependency of Life Span Prolongation of F344/DuCrj Rats Injected with (−)deprenyl

Content Provider	Springer Nature Link
Author	Kitani, K. Kanai, S. Miyasaka, K. Carrillo, M. C. Ivy, G. O.
Copyright Year	2005
Abstract	The effect of (−)deprenyl (D) on prolonging survival has previously been reported in different species of animals. In rats, three studies reported a positive effect, while one study reported a shortening of life spans. In the present study, we attempted to clarify past discrepancies in the results based on the speculation that there exists a certain effective dose range for this effect of the drug. F344/DuCrj rats of both sexes began to receive subcutaneous (s.c.) injections of D at the age of 18 months at a dose of 0.25 mg/kg/injection (inj.), 3 times a week. Control animals were given a vehicle (a saline solution). Average life spans of animals (days) were significantly increased in both male (895 ± 109.7, n=30; 967.8 ± 88.6, n=30, control vs. D treated, P<0.01, t-test) and female (924.7 ± 132.2, n=38; 987.1 ± 133.4, n=39, P<0.05) rats by 8.1% and 6.7%, respectively. We have previously reported that a dose of 0.5mg/kg/inj. (s.c.) significantly increased the life span of male F344 rats, while a dose of 1.0 mg/kg/inj. somewhat shortened the life span, although the difference was not statistically significant. The results of the present study coupled with our previous reports clearly indicate that a proper dose of D within a certain dose range can significantly increase the life span of animals of both sexes, but that a greater dose becomes less effective and may actually adversely affect the life span of rats. The presence of this effective dose range of D may explain discrepancies in the effect of D on life spans of animals previously reported.
Starting Page	297
Ending Page	302
Page Count	6
File Format	PDF
ISSN	13895729
Journal	Biogerontology
Volume Number	6
Issue Number	5
e-ISSN	15736768
Language	English
Publisher	Kluwer Academic Publishers
Publisher Date	2005-01-01
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	antioxidant enzymes (−)deprenyl F344 male and female rats optimal dose range specific pathogen free rats survival prolongation Geriatrics/Gerontology Cell Biology Developmental Biology
Content Type	Text
Resource Type	Article
Subject	Aging Gerontology Geriatrics and Gerontology

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