NDLI: Genome-wide analysis of low-dose irradiated male Drosophila melanogaster with extended longevity

Content Provider	Springer Nature Link
Author	Seong, Ki Moon Kim, Cha Soon Seo, Sun Won Jeon, Ha Yeon Lee, Byung Sub Nam, Seon Young Yang, Kwang Hee Kim, Ji Young Kim, Chong Soon Min, Kyung Jin Jin, Young Woo
Copyright Year	2010
Abstract	Ionizing radiation generates oxidative stress, which is thought to be a major cause of aging. Although living organisms are constantly exposed to low levels of radiation, most studies examining the effect of radiation have focused on accelerated aging and diminished life span that result from high-dose radiation. On the other hand, several studies have suggested that low-dose radiation enhances the longevity of Drosophila melanogaster. Therefore, investigation of the biological effects of low-dose radiation could contribute to a more comprehensive understanding of the aging process. In this study, microarray and quantitative real time-PCR were used to measure genome-wide changes in transcript levels in low-dose irradiated fruit flies that showed enhanced longevity. In response to radiation, approximately 13% of the genome exhibited changes in gene expression, and a number of aging-related genes were significantly regulated. These data were compared with quantitative trait loci affecting life-span to identify candidate genes involved in enhanced longevity induced by low-dose radiation. This genome-wide survey revealed novel information about changes in transcript levels in low-dose irradiated flies and identified 39 new candidate genes for molecular markers of extended longevity induced by ionizing radiation. In addition, this study also suggests a mechanism by which low-dose radiation extends longevity.
Starting Page	93
Ending Page	107
Page Count	15
File Format	PDF
ISSN	13895729
Journal	Biogerontology
Volume Number	12
Issue Number	2
e-ISSN	15736768
Language	English
Publisher	Springer Netherlands
Publisher Date	2010-07-09
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Life span Low-dose radiation Microarray gene expression Drosophila aging Geriatrics/Gerontology Cell Biology Developmental Biology
Content Type	Text
Resource Type	Article
Subject	Aging Gerontology Geriatrics and Gerontology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Genome-wide analysis of low-dose irradiated male Drosophila melanogaster with extended longevity

Radiation-induced life span alteration of Drosophila lines with genotype differences

Life span extension in Drosophila melanogaster induced by morphine

The gene cluster hypothesis of aging and longevity

Hormetic efficacy of rutin to promote longevity in Drosophila melanogaster

Fecundity and life span in transgenic Drosophila melanogaster overexpressing hsp70

Life span alteration after irradiation in Drosophila melanogaster strains with mutations of Hsf and Hsps

Cold stress increases resistance to fungal infection throughout life in Drosophila melanogaster

Life extension in Drosophila maintained under lengthened light/dark regime

Genome-wide analysis of low-dose irradiated male Drosophila melanogaster with extended longevity

Similar Documents

Genome-wide analysis of low-dose irradiated male Drosophila melanogaster with extended longevity

Radiation-induced life span alteration of Drosophila lines with genotype differences

Life span extension in Drosophila melanogaster induced by morphine

The gene cluster hypothesis of aging and longevity

Hormetic efficacy of rutin to promote longevity in Drosophila melanogaster

Fecundity and life span in transgenic Drosophila melanogaster overexpressing hsp70

Life span alteration after irradiation in Drosophila melanogaster strains with mutations of Hsf and Hsps

Cold stress increases resistance to fungal infection throughout life in Drosophila melanogaster

Life extension in Drosophila maintained under lengthened light/dark regime

Genome-wide analysis of low-dose irradiated male Drosophila melanogaster with extended longevity