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| Content Provider | Springer Nature Link |
|---|---|
| Author | Yashin, Anatoli I. Arbeev, Konstantin G. Akushevich, Igor Ukraintseva, Svetlana V. Kulminski, Alexander Arbeeva, Liubov S. Culminskaya, Irina |
| Copyright Year | 2009 |
| Abstract | Exceptional survival results from complicated interplay between genetic and environmental factors. The effects of these factors on survival are mediated by the biological and physiological variables, which affect mortality risk. In this paper, we evaluated the role of blood glucose (BG) in exceptional survival using the Framingham heart study data for the main (FHS) and offspring (FHSO) cohorts. We found that: (1) the average cross-sectional age patterns of BG change over time; (2) the values of BG level among the longest lived individuals in this study differ for different sub-cohorts; (3) the longitudinal age patterns of BG differ from those of cross-sectional ones. We investigated mechanisms forming average age trajectories of BG in the FHS cohort. We found that the two curves: one, characterizing the average effects of allostatic adaptation, and another, minimizing mortality risk for any given age, play the central role in this process. We found that the average BG age trajectories for exceptional survivors are closer to the curve minimizing mortality risk than those of individuals having shorter life spans. We concluded that individuals whose age trajectories of BG are located around the curve minimizing chances of premature death at each given age have highest chances of reaching exceptional longevity. |
| Starting Page | 257 |
| Ending Page | 265 |
| Page Count | 9 |
| File Format | |
| ISSN | 13895729 |
| Journal | Biogerontology |
| Volume Number | 11 |
| Issue Number | 3 |
| e-ISSN | 15736768 |
| Language | English |
| Publisher | Springer Netherlands |
| Publisher Date | 2009-07-31 |
| Publisher Place | Dordrecht |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Mortality risk Stochastic process model of aging Allostatic adaptation Age-specific physiological norm Blood glucose Framingham heart study Developmental Biology Geriatrics/Gerontology Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Aging Gerontology Geriatrics and Gerontology |
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