Insights on aging and exceptional longevity from longitudinal data: novel findings from the Framingham Heart Study.

Content Provider	Europe PMC
Author	Yashin, Anatoli I. Akushevich, Igor V. Arbeev, Konstantin G. Akushevich, Lucy Ukraintseva, Svetlana V. Kulminski, Aliaksandr
Abstract	Age trajectories of physiological indices contain important information about aging-related changes in the human organism and therefore may help us understand human longevity. The goal of this study is to investigate whether shapes of such trajectories earlier in life affect the residual life span distribution. We used longitudinal limited access data from seven physiological indices and life spans of respective individuals collected in the Framingham Heart Study (FHS). These include: diastolic blood pressure (DBP), pulse pressure (PP), body mass index (BMI), serum cholesterol (SCH), blood glucose (BG), hematocrit (HC), and pulse rate (PR). We developed a method for assigning individuals to groups of potentially long-lived (PLL) and potentially medium-lived (PML) groups using age trajectories of physiological indices at the age interval between 40 and 60 years. The analysis shows that the longevity of individuals who survived to age of 65 depends on the behavior of the physiological indices between 40 and 60 years of age.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC1994150&blobtype=pdf
ISSN	01619152
Volume Number	28
DOI	10.1007/s11357-006-9023-7
PubMed Central reference number	PMC1994150
Issue Number	4
PubMed reference number	17895962
Journal	Age [Age (Dordr)]
e-ISSN	15744647
Language	English
Publisher	Kluwer Academic Publishers
Publisher Date	2006-12-01
Publisher Place	Dordrecht
Access Restriction	Open
Rights License	© American Aging Association, Media, PA, USA 2006
Subject Keyword	Age trajectories Aging Exceptional longevity Longitudinal data Physiological indices The Framingham Heart Study
Content Type	Text
Resource Type	Article
Subject	Aging Geriatrics and Gerontology