NDLI: Gompertz law and aging as exclusion effects

Content Provider	Springer Nature Link
Author	Hallén, Anund
Copyright Year	2007
Abstract	The exponential increase with age in mortality rate, the Gompertz law, indicates that the decrease in vitality and viability linked to aging depends on phenomena with exponential or logarithmic dynamics. Gompertz slope (α) is assumed to be a measure of aging rate, provided the studied cohort is homogeneous and in a supporting environment. The law provides no clue about the cause of aging, but may be formally correlated with various physical or mathematical functions. A possible correlation between the Ogston–Laurent exclusion equation and human aging is examined. An increase with age of an inert cross-linked insoluble protein network is assumed to result in a logarithmic decrease in water volume available to colloidal macromolecules. In this model, α is assumed to be a measure of the rate of accumulation of the polypeptide network.
Starting Page	605
Ending Page	612
Page Count	8
File Format	PDF
ISSN	13895729
Journal	Biogerontology
Volume Number	8
Issue Number	5
e-ISSN	15736768
Language	English
Publisher	Springer Netherlands
Publisher Date	2007-07-24
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Aging Exclusion Gompertz slope Insoluble protein network Developmental Biology Geriatrics/Gerontology Cell Biology
Content Type	Text
Resource Type	Article
Subject	Aging Gerontology Geriatrics and Gerontology

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Gompertz law and aging as exclusion effects