NDLI: Variable effects of vitamin E on Drosophila longevity

Content Provider	Springer Nature Link
Author	Driver, Christopher Georgeou, Angela
Copyright Year	2003
Abstract	Vitamin E has been used widely ininvertebrate experiments where it usually acts to prolong life span. Conversely in vertebrates it has been less successful. In some cases, experiments in rodents show no effect of vitamin E on longevity. Consequently, the suggestion has been made that anti-oxidants do not effect ageing in vertebrates. In more extensive experiments with Drosophila melanogaster, vitamin E exerted both life span extending and toxic effects. At 20 µg/ml,the life span was increased by 16%, although there was no effect at higher or lower concentrations. At 200 µg/ml, vitamin E protected Drosophila against paraquat toxicity. At this concentration, vitamin E had no effect on longevity in one set of experiments, and shortened the life span in another set. Apparent toxicity of vitamin E was also observed in behavior experiments. We suggest that inactivity of vitamin E that has been reported by some authors is due to antagonistic actions of a toxic effect and a beneficial anti-oxidant action. This complex response to vitamin E will limit its use for clinical and investigative work on ageing.
Starting Page	91
Ending Page	95
Page Count	5
File Format	PDF
ISSN	13895729
Journal	Biogerontology
Volume Number	4
Issue Number	2
e-ISSN	15736768
Language	English
Publisher	Kluwer Academic Publishers
Publisher Date	2003-01-01
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Geriatrics/Gerontology Cell Biology Developmental Biology
Content Type	Text
Resource Type	Article
Subject	Aging Gerontology Geriatrics and Gerontology

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