NDLI: Lack of hypergravity-associated longevity extension in Drosophila melanogaster flies overexpressing hsp70

Content Provider	Springer Nature Link
Author	Le Bourg, Éric Valenti, Philippe Payre, François
Copyright Year	2002
Abstract	Previous studies have shown that Drosophila melanogaster males live longer if exposed to hypergravity at young age. Similarly, thermotolerance and climbing activity in old age are enhanced and it has been hypothetized that the 70 kDa inducible heat-shock protein (hsp70) may play a role in some of these effects. In this article, longevity, thermotolerance and climbing activity were studied in transgenic flies (OE+strain) over expressing hsp70 and in control flies harboring the transfection vector at the same chromosomal location but no extra-copies of the hsp70 gene (OE−strain). No positive effect from exposure to hypergravity at a young age was observed for longevity and climbing activity. Thermotolerance was increased by hypergravity but to the same extent in OE+ and OE− strains. Since no positive effect from hypergravity exposure or similar effects were observed in the two strains, it may be concluded that over expression ofhsp70 does not provide an advantage to flies subjected to a mild stress and that it may not be of any help during aging.
Starting Page	355
Ending Page	364
Page Count	10
File Format	PDF
ISSN	13895729
Journal	Biogerontology
Volume Number	3
Issue Number	6
e-ISSN	15736768
Language	English
Publisher	Kluwer Academic Publishers
Publisher Date	2002-01-01
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Geriatrics/Gerontology Cell Biology Developmental Biology
Content Type	Text
Resource Type	Article
Subject	Aging Gerontology Geriatrics and Gerontology

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