NDLI: Introgression of Brown Norway Chromosome 13 Improves Visual Spatial Memory in the Dahl S Rat

Content Provider	Springer Nature Link
Author	Kerr, Abigail L. Hensel, Megan L. Peterson, Todd C. Villatoro, Lee O. Nye, Steven H. Swain, Rodney A.
Copyright Year	2009
Abstract	The present study was conducted in an effort to evaluate whether chromosomal substitution can repair impaired exploration learning and memory. It has previously been observed that Dahl salt-sensitive (SS) rodents exhibit impaired cognitive function along with abnormal physiological responses to muscle stimulation. Introgression of Brown Norway chromosome (13BN) has been found to restore normal physiological processes in SS animals. However, the effect of chromosomal substitution on cognitive performance has not been explored. It was hypothesized that 13BN also rescues cognitive impairments in these animals. Visual spatial learning and cognitive flexibility were evaluated using the Morris water maze (MWM) and the T-maze. This manipulation is effective in rescuing impaired task acquisition, but not perseveration observed in the SS animal. These animals may represent a natural animal model in which to isolate genetic information responsible for learning and memory function.
Starting Page	76
Ending Page	84
Page Count	9
File Format	PDF
ISSN	00018244
Journal	Behavior Genetics
Volume Number	40
Issue Number	1
e-ISSN	15733297
Language	English
Publisher	Springer US
Publisher Date	2009-09-09
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Consomic Chromosomal substitution Cognitive flexibility SS-13BN Visuospatial memory Public Health/Gesundheitswesen Health Psychology Clinical Psychology
Content Type	Text
Resource Type	Article
Subject	Genetics Ecology, Evolution, Behavior and Systematics Genetics (clinical)

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Substitution of Brown Norway chromosome 16 preserves cardiac function with aging in a salt-sensitive Dahl consomic rat

INTROGRESSION OF BROWN NORWAY CYP4A GENES ONTO THE DAHL SALT-SENSITIVE BACKGROUND RESTORES VASCULAR FUNCTION IN SS-5BN CONSOMIC RATS

Introgression of Brown Norway Chromosome 1 onto the Fawn Hooded Hypertensive Background Rescues Long-Term Fear Memory Deficits

Mechanisms of cardioprotection resulting from Brown Norway chromosome 16 substitution in the salt-sensitive Dahl rat

Mechanism of Differential Cardiovascular Response to Propofol in Dahl Salt-Sensitive, Brown Norway, and Chromosome 13-Substituted Consomic Rat Strains: Role of Large Conductance Ca2+ and Voltage-Activated Potassium Channels

Narrowing a region on rat chromosome 13 that protects against hypertension in Dahl SS-13BN congenic strains

Using space to remember: Short-term spatial structure spontaneously improves working memory

Analysis of metabolites in plasma reveals distinct metabolic features between Dahl salt-sensitive rats and consomic SS.13BN rats

Chromosomal Assignment of Quantitative Trait Loci Influencing Modified Hole Board Behavior in Laboratory Mice using Consomic Strains, with Special Reference to Anxiety-related Behavior and Mouse Chromosome 19

Introgression of Brown Norway Chromosome 13 Improves Visual Spatial Memory in the Dahl S Rat

Similar Documents

Substitution of Brown Norway chromosome 16 preserves cardiac function with aging in a salt-sensitive Dahl consomic rat

INTROGRESSION OF BROWN NORWAY CYP4A GENES ONTO THE DAHL SALT-SENSITIVE BACKGROUND RESTORES VASCULAR FUNCTION IN SS-5BN CONSOMIC RATS

Introgression of Brown Norway Chromosome 1 onto the Fawn Hooded Hypertensive Background Rescues Long-Term Fear Memory Deficits

Mechanisms of cardioprotection resulting from Brown Norway chromosome 16 substitution in the salt-sensitive Dahl rat

Mechanism of Differential Cardiovascular Response to Propofol in Dahl Salt-Sensitive, Brown Norway, and Chromosome 13-Substituted Consomic Rat Strains: Role of Large Conductance Ca2+ and Voltage-Activated Potassium Channels

Narrowing a region on rat chromosome 13 that protects against hypertension in Dahl SS-13BN congenic strains

Using space to remember: Short-term spatial structure spontaneously improves working memory

Analysis of metabolites in plasma reveals distinct metabolic features between Dahl salt-sensitive rats and consomic SS.13BN rats

Chromosomal Assignment of Quantitative Trait Loci Influencing Modified Hole Board Behavior in Laboratory Mice using Consomic Strains, with Special Reference to Anxiety-related Behavior and Mouse Chromosome 19

Introgression of Brown Norway Chromosome 13 Improves Visual Spatial Memory in the Dahl S Rat