NDLI: Introgression of Brown Norway Chromosome 1 onto the Fawn Hooded Hypertensive Background Rescues Long-Term Fear Memory Deficits

Content Provider	Springer Nature Link
Author	Jarome, Timothy J. Kwapis, Janine L. Nye, Steven H. Helmstetter, Fred J.
Copyright Year	2009
Abstract	The isolation of genes influencing long-term memory is critical for an understanding of learning at the molecular level. Recently, chromosomal substitution rat strains, known as consomics, have been developed. Here we report the results of the first study on aversive learning and memory with these consomic rats. We compared the Fawn Hooded Hypertensive (FHH) and Brown Norway (BN) parent strains with a Brown Norway chromosome 1 substitution on the FHH background (FHH-1BN). Results indicated that while all strains had normal short-term memory, the FHH animals were impaired relative to BN in tests of long-term memory for a discrete auditory cue. This deficit was rescued by the introgression of the BN1 chromosome onto the FHH background. Furthermore, the FHH-1BN consomic showed an enhancement in long-term contextual fear memory relative to the FHH strain. These changes were not due to differences in pain sensitivity as both strains performed equally on two different pain tests. These results provide preliminary support that consomic rat strains can be a useful tool in identifying genes related to long-term fear memory formation.
Starting Page	85
Ending Page	92
Page Count	8
File Format	PDF
ISSN	00018244
Journal	Behavior Genetics
Volume Number	40
Issue Number	1
e-ISSN	15733297
Language	English
Publisher	Springer US
Publisher Date	2009-09-16
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Consomics Fear conditioning Learning Memory QTL Rats Public Health/Gesundheitswesen Health Psychology Clinical Psychology
Content Type	Text
Resource Type	Article
Subject	Genetics Ecology, Evolution, Behavior and Systematics Genetics (clinical)

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Introgression of Brown Norway Chromosome 13 Improves Visual Spatial Memory in the Dahl S Rat

Identification of a QTL on chromosome 1 for impaired autoregulation of RBF in fawn-hooded hypertensive rats.

Congenic Mouse Strains Enable Discrimination of Genetic Determinants Contributing to Fear and Fear Memory

A Growth QTL on Chicken Chromosome 1 Affects Emotionality and Sociality

Rapid Selection Response for Contextual Fear Conditioning in a Cross Between C57BL/6J and A/J: Behavioral, QTL and Gene Expression Analysis

Chronic Hypoxia Effects Active Tone Differently in the Pulmonary Arteries of Brown-Norway, Spraque-Dawley, and Fawn-Hooded Rats

Effect of Domestication on Aggression in Gray Norway Rats

Genome-Wide Association for Fear Conditioning in an Advanced Intercross Mouse Line

Long-term memory deficits in pavlovian fear conditioning (2006).

Introgression of Brown Norway Chromosome 1 onto the Fawn Hooded Hypertensive Background Rescues Long-Term Fear Memory Deficits

Similar Documents

Introgression of Brown Norway Chromosome 13 Improves Visual Spatial Memory in the Dahl S Rat

Identification of a QTL on chromosome 1 for impaired autoregulation of RBF in fawn-hooded hypertensive rats.

Congenic Mouse Strains Enable Discrimination of Genetic Determinants Contributing to Fear and Fear Memory

A Growth QTL on Chicken Chromosome 1 Affects Emotionality and Sociality

Rapid Selection Response for Contextual Fear Conditioning in a Cross Between C57BL/6J and A/J: Behavioral, QTL and Gene Expression Analysis

Chronic Hypoxia Effects Active Tone Differently in the Pulmonary Arteries of Brown-Norway, Spraque-Dawley, and Fawn-Hooded Rats

Effect of Domestication on Aggression in Gray Norway Rats

Genome-Wide Association for Fear Conditioning in an Advanced Intercross Mouse Line

Long-term memory deficits in pavlovian fear conditioning (2006).

Introgression of Brown Norway Chromosome 1 onto the Fawn Hooded Hypertensive Background Rescues Long-Term Fear Memory Deficits