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Behavior Genetics : Volume 30, Issue 1, January 2000

Behavior Genetics : Volume 29

Behavior Genetics : Volume 28

Behavior Genetics : Volume 27

Mice Lacking PKCγ Exhibit Decreased Anxiety

Content Provider	Springer Nature Link
Author	Bowers, Barbara J. Collins, Allan C. Tritto, Theresa Wehner, Jeanne M.
Copyright Year	2000
Abstract	To investigate the contribution of the PKCγ isoform of protein kinase C (PKC) in neurochemical pathways regulating anxiety, mice lacking the gene encoding PKCγ were tested with heterozygote and wild-type littermates in three approach-avoidance tests of anxiety. Null mutant mice consistently displayed a decrease in baseline anxiety-related behaviors in the elevated plus-maze, the black/white box, and the mirrored chamber. In the elevated plus-maze, mutant mice entered the open arms significantly more often and spent more time in the open arms of the maze. In the black/white box, transitions between the compartments were greatest in the null mutant mice, and in the mirrored chamber, mutant mice were markedly less anxious with significantly decreased latencies to enter and more time spent in the chamber. Indices of locomotor activity in the mazes and tests of activity in home cages indicated that the reduced anxiety observed in the mutant mice was not due to baseline locomotor activity differences among the genotypes. These results suggest that PKCγ be considered as one factor in the etiology of anxiety, perhaps via its post-synaptic regulation of GABAA and 5-HT2 receptors, two receptors implicated in the neurobiology of anxiety.
Starting Page	111
Ending Page	121
Page Count	11
File Format	PDF
ISSN	00018244
Journal	Behavior Genetics
Volume Number	30
Issue Number	2
e-ISSN	15733297
Language	English
Publisher	Kluwer Academic Publishers-Plenum Publishers
Publisher Date	2000-01-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Human Genetics Neurosciences Evolutionary Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Ecology, Evolution, Behavior and Systematics Genetics (clinical)

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