NDLI: A New Genetic Variant of MDX Mice: Study of the Phenotype

Content Provider	Springer Nature Link
Author	Krivov, L. I. Stenina, M. A. Yarygin, V. N. Polyakov, A. V. Savchuk, V. I. Obrubov, S. A. Komarova, N. V.
Copyright Year	2009
Abstract	Genetic selection in a colony of mdx mice (suffering from X-chromosome-linked muscular dystrophy) resulted in generation of their new genetic variant. In this new variant, the genetic, biochemical, and histological markers of muscular dystrophy are combined with signs of oculocutaneous albinism (skin and fur depigmentation), transillumination of the iris, sharply reduced pigmentation of the retinal epithelium, and increase of the eyeball refraction). Two sensorimotor tests (negative geotaxis and wire back down hanging) detected other phenotypical characteristics of albino mdx mice carrying, in addition to the mutation in the dystrophin gene exon 23 (intrinsic of the “classical” black mdx mice), an extra mutation responsible for pigmentation disorders. Slow geotaxis, despite longer wire back down hanging capacity, was regarded as aggravation of the neurological dysfunction in albino mdx mice in comparison with black mdx mice.
Starting Page	625
Ending Page	629
Page Count	5
File Format	PDF
ISSN	00074888
Journal	Bulletin of Experimental Biology and Medicine
Volume Number	147
Issue Number	5
e-ISSN	15738221
Language	English
Publisher	Springer US
Publisher Date	2009-09-16
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	mdx mice genetics behavioral phenotype Duchenne’s progressive muscular dystrophy Laboratory Medicine Pathology Cell Biology Internal Medicine Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry, Genetics and Molecular Biology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Hereditary muscular dystrophy in MDX mice as a homologous model for introduction of cell technologies in the treatment of progressive muscular dystrophies in humans

Effect of head-down hanging on the course of degenerative process in the hind paw muscles of 12-month-old MDX mice

Phenotypic Differences between mdx Black Mice and mdx Albino Mice. Comparison of Cytokine Levels in the Blood

Restoration of gastrocnemius muscle in mdx mice of different age after injury and implantation of xenogenic muscle tissue

Cytokine profile of the blood in mice with normal and abnormal heart rhythm

Behavioral effect of terahertz waves in male mice

Genetic Variability of Spermatozoon Production and Morphology in Laboratory Mice

Dynamics of Behavioral Disorders in Transgenic Mice with Modeled Alzheimer’s Disease

What has the mdx mouse model of duchenne muscular dystrophy contributed to our understanding of this disease?

A New Genetic Variant of MDX Mice: Study of the Phenotype

Similar Documents

Hereditary muscular dystrophy in MDX mice as a homologous model for introduction of cell technologies in the treatment of progressive muscular dystrophies in humans

Effect of head-down hanging on the course of degenerative process in the hind paw muscles of 12-month-old MDX mice

Phenotypic Differences between mdx Black Mice and mdx Albino Mice. Comparison of Cytokine Levels in the Blood

Restoration of gastrocnemius muscle in mdx mice of different age after injury and implantation of xenogenic muscle tissue

Cytokine profile of the blood in mice with normal and abnormal heart rhythm

Behavioral effect of terahertz waves in male mice

Genetic Variability of Spermatozoon Production and Morphology in Laboratory Mice

Dynamics of Behavioral Disorders in Transgenic Mice with Modeled Alzheimer’s Disease

What has the mdx mouse model of duchenne muscular dystrophy contributed to our understanding of this disease?

A New Genetic Variant of MDX Mice: Study of the Phenotype