NDLI: Effect of Mouse Chromosome 13 Terminal Fragment on Liability to Catalepsy and Expression of Tryptophane Hydroxylase-2, Serotonin Transporter, and 5-HT1A Receptor Genes in the Brain

Content Provider	Springer Nature Link
Author	Kulikov, A. V. Naumenko, V. S. Bazovkina, D. V. Dee, V. Yu. Osipova, D. V. Popova, N. K.
Copyright Year	2009
Abstract	Congenic mice obtained by genome fragments transfer from one strain to another are a potent tool for studies of the molecular mechanisms of behavioral mutations. The 59-70 cM fragment of chromosome 13 containing the locus determining predisposition to freezing reaction (catalepsy) and the gene encoding 5-HT1A receptor were transferred from cataleptic CBA/Lac mice into the genome of catalepsy-resistant AKR/J mice. The impact of this fragment for the severity of catalepsy and expression of genes encoding tryptophane hydroxylase-2, serotonin transporter, and 5-HT1A receptor was studied. Half of mice of the resultant congenic AKR.CBA-D13Mit76 strain exhibited pronounced catalepsy, similarly to donor CBA animals. The expression of 5-HT1A receptor gene in the midbrain of AKR animals was significantly higher than in CBA. The level of 5-HT1A receptor mRNA in AKR.CBA-D13Mit76 animals was significantly higher than in the donor strain. Mice of parental AKR and CBA strains did not differ from each other and from AKR.CBA-D13Mit76 animals by the levels of tryptophane hydroxylase-2 and serotonin transporter genes mRNA. These data prove the location of catalepsy regulating gene in the distal fragment of chromosome 13. The recipient strain genome enhanced the expression of 5-HT1A receptor gene in the brain without modulating the expression of catalepsy gene.
Starting Page	621
Ending Page	624
Page Count	4
File Format	PDF
ISSN	00074888
Journal	Bulletin of Experimental Biology and Medicine
Volume Number	147
Issue Number	5
e-ISSN	15738221
Language	English
Publisher	Springer US
Publisher Date	2009-09-16
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	congenic mice hereditary catalepsy 5-HT1A receptor gene tryptophane hydroxylase-2 5-HT-transporter Laboratory Medicine Pathology Cell Biology Internal Medicine Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry, Genetics and Molecular Biology

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