NDLI: Effect of Long-Term Stress on H3Ser10 Histone Phosphorylation in Neuronal Nuclei of the Sensorimotor Cortex and Midbrain Reticular Formation in Rats with Different Nervous System Excitability

Content Provider	Springer Nature Link
Author	Pavlova, M. B. Dyuzhikova, N. A. Shiryaeva, N. V. Savenko, Yu. N. Vaido, A. I.
Copyright Year	2013
Abstract	The effects of long-term mental and pain stress on H3Ser10 histone phosphorylation in neurons of the the sensorimotor corex and midbrain reticular formation were studied 24 h, 2 weeks, and 2 months after exposure of rats differing by the nervous system excitability. Rats with high excitability threshold exhibited higher basal level of H3Ser10 histone phosphorylation in the midbrain reticular formation neurons than rats with low excitability threshold. The sensorimotor cortical neurons of the two strains did not differ by this parameter. Stress led to a significant increase in the counts of immunopositive neuronal nuclei in rats with low excitability threshold: the parameter increased significantly in the sensorimotor cortex 24 h after exposure and normalized in 2 weeks after neurotization. In the midbrain reticular formation of this rat strain stress stimulated H3Ser10 histone phosphorylation after 24 h and after 2 weeks; the parameter normalized after neurotization in 2 months. Hence, genetically determined level of the nervous system excitability was essential for the basal level of neuron phosphorylation and for the time course of this process after long-term exposure to mental and pain stress, depending on the brain structure. A probable relationship between H3Ser10 histone phosphorylation process and liability to obsessive compulsive mental disorders in humans was discussed.
Starting Page	373
Ending Page	375
Page Count	3
File Format	PDF
ISSN	00074888
Journal	Bulletin of Experimental Biology and Medicine
Volume Number	155
Issue Number	3
e-ISSN	15738221
Language	English
Publisher	Springer US
Publisher Date	2013-07-19
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	stress sensorimotor cortex midbrain reticular formation H3 histone highly excitable and nonexcitable rat strains Biomedicine general Internal Medicine Cell Biology Pathology Laboratory Medicine
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry, Genetics and Molecular Biology

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