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| Content Provider | Springer Nature Link |
|---|---|
| Author | Menshchikova, E. B. Zenkov, N. K. Tkachev, V. O. Lemza, A. E. Kandalintseva, N. V. |
| Copyright Year | 2013 |
| Abstract | The protective effect of partially substituted monophenol TS-13 inducing the Nrf2/Keap1/ARE signaling system was studied on the model of chronic inflammation in vivo. It was found that during simulation of inflammation in an air pouch lined with synovial-like membrane, ТS-13 did not affect the exudate volume, protein content, and cell count, but significantly reduced the intensity of oxidative metabolism in leukocytes of the exudate. In rheumatoid polyarthritis induced by heterologous collagen, TS-13 reduced the severity of clinical signs of inflammation only at the early stages, but inhibited H2O2 generation by monocytes and, partially, by blood neutrophils. These results suggest that the phlogolytic effect of the redox sensitive Nrf2/Keap1/ARE signaling system is less pronounced in chronic immune-mediated inflammatory processes than in acute inflammation. |
| Starting Page | 330 |
| Ending Page | 334 |
| Page Count | 5 |
| File Format | |
| ISSN | 00074888 |
| Journal | Bulletin of Experimental Biology and Medicine |
| Volume Number | 155 |
| Issue Number | 3 |
| e-ISSN | 15738221 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2013-07-19 |
| Publisher Place | Boston |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | phenol antioxidant TS-13 Nrf2/Keap1/ARE signaling system chronic inflammation air pouch collagen-induced arthritis Biomedicine general Internal Medicine Cell Biology Pathology Laboratory Medicine |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Biochemistry, Genetics and Molecular Biology |
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