NDLI: Changes in Electrical Properties of Command Neurons during Protective Effect of Low Doses of Antibodies to S100 Protein on the Development of Long-Term Sensitization in Helix lucorum

Content Provider	Springer Nature Link
Author	Timoshenko, A. Kh. Andriav, V. V. Gainutdiva, T. Kh. Gainutdiv, Kh. L. Murava, L. N. Tagirova, R. R. Shtark, M. B. Epstein, O. I.
Copyright Year	2009
Abstract	We studied the effect of antibodies to Ca2+-binding protein S100 in a dilution of 10−12 (LATS100) on the development of long-term sensitization in Helix lucorum, a neurobiological model of anxious and depressive states. After administration of LAT-S100 preventing the development of long-term sensitization before training, the membrane and threshold potentials in command neurons regulating defense behavior decreased less markedly than during longterm sensitization. It is assumed that the “protective” effect is associated with mechanisms of long-term potential maintenance and changes in intra- and extracellular balance of Ca2+- binding protein S100.
Starting Page	598
Ending Page	601
Page Count	4
File Format	PDF
ISSN	00074888
Journal	Bulletin of Experimental Biology and Medicine
Volume Number	148
Issue Number	4
e-ISSN	15738221
Language	English
Publisher	Springer US
Publisher Date	2010-03-25
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Ca2+-binding protein S100 antibodies to S100 long-term sensitization neurobiological model of anxiety and depression membrane and threshold potential Laboratory Medicine Pathology Cell Biology Internal Medicine Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry, Genetics and Molecular Biology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Changes in Electrical Properties of Command Neurons during Protective Effect of Low Doses of Antibodies to S100 Protein on the Development of Long-Term Sensitization in Helix lucorum