NDLI: Phagocytic Activity of Macrophages against Liposomes with Conjugates of Oxidized Dextrans and Isonicotinic Acid Hydrazide during Modeling of Phagocytosis Disturbances In Vitro

Content Provider	Springer Nature Link
Author	Arkhipov, S. A. Shkurupy, V. A. Troitsky, A. V. Luzgina, N. G. Ufimceva, E. G. Zaikovskaja, M. V. Iljine, D. A. Akhramenko, E. S. Gulyaeva, E. P. Bistrova, T. N.
Copyright Year	2009
Abstract	We studied phagocytic activity of macrophages against molecular-liposome hybrid compositions consisting of liposomes (diameter 200–450 nm) containing oxidized dextrans with a molecular weight of 35 or 60 kDa conjugated with the basic antituberculosis preparation isonicotinic acid hydrazide (dextrazides) during modeling of various disturbances of endocytosis function of phagocytic cells in vitro. Preincubation of macrophages with trypsin, colchicine, or sodium azide did not change the parameters of adhesion of molecular-liposome hybrid compositions to macrophages. It was found that preincubation of cells with colchicine or sodium azide reduced parameters of phagocytosis of the molecular-liposome hybrid compositions; this reduction did not depend on the molecular weight of dextrans entering the composition of the molecular-liposome hybrid compositions.
Starting Page	689
Ending Page	691
Page Count	3
File Format	PDF
ISSN	00074888
Journal	Bulletin of Experimental Biology and Medicine
Volume Number	148
Issue Number	4
e-ISSN	15738221
Language	English
Publisher	Springer US
Publisher Date	2010-03-26
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	oxidized dextrans isonicotinic acid hydrazide liposomes phagocytosis macrophages Laboratory Medicine Pathology Cell Biology Internal Medicine Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry, Genetics and Molecular Biology

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