NDLI: Immunohistochemical Analysis of MMP-2 Expression in the Myocardium During the Postinfarction Period

Content Provider	Springer Nature Link
Author	Nepomnyashchikh, L. M. Lushnikova, E. L. Bakarev, M. A. Nikityuk, D. B. Yuzhik, E. I. Mzhelskaya, M. M. Nepomnyashchikh, R. D. Klinnikova, M. G. Karpova, A. A.
Copyright Year	2015
Abstract	Immunohistochemical analysis revealed 2.5-fold increased of expression MMP-2 in myocardium samples during the early period (up to 3 days) of postinfarction reparative regeneration. During this period, MMP-2 was detected mainly in monocytes/macrophages circulating in the blood and migrating to the necrotic zone, while expression in the intermuscular and perivascular connective tissue was lower. At later terms, with development of large focal and diffuse cardiosclerosis, MMP-2 expression significantly decreased (to the initial level) and was detected mainly in the foci of intermuscular and perivascular fibrosis, its area in the sections increased by 1.8 times. Evaluation of MMP-2 expression in the blood vessels showed that the immunohistochemical reaction was the most pronounced in the walls of new sinusoidal vessels and the minimum in the intramural arteries of medium diameter. These results attest to an important role of MMP in connective tissue remodeling (proteolytic degradation) during the early period of postinfarction reparative regeneration. The decrease in MMP-2 expression observed at later terms correlated with myocardial fibrosis progression.
Starting Page	505
Ending Page	510
Page Count	6
File Format	PDF
ISSN	00074888
Journal	Bulletin of Experimental Biology and Medicine
Volume Number	159
Issue Number	4
e-ISSN	15738221
Language	English
Publisher	Springer US
Publisher Date	2015-09-22
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	myocardial infarction cardiofi brosis matrix metalloproteinase-2 immunohistochemistry Biomedicine general Internal Medicine Cell Biology Pathology Laboratory Medicine
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry, Genetics and Molecular Biology

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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