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| Content Provider | Springer Nature Link |
|---|---|
| Author | Jumagazieva, D. S. Maslyakova, G. N. Suleymava, L. V. Bucharskaya, A. B. Firsova, S. S. Khlebtsov, B. N. Terentyuk, G. S. Kong, S. M. Khlebtsov, N. G. |
| Copyright Year | 2011 |
| Abstract | Mutagenic activity of gold nanoparticles of different sizes were studied by micronucleus assay. Karyological analysis was performed and the count of micronucleoli in interphase bone marrow polychromatic erythrocytes in white outbred rats was determined. The animals orally received gold nanoparticles 16 and 55 nm in diameter and gold nanoshells 160 nm in diameter once a day for 7 days in a dose of 0.25 mg gold/kg. To ensure stability and biocompatibility, the surface of nanoparticles was functionalized with polyethylene glycol molecules. There were no signifi cant differences in the number of micronucleoli in comparison with the control group, which suggests that gold nanoparticles of the specifi ed size administered orally in the specifi ed doses do not exhibit mutagenic activity. |
| Starting Page | 731 |
| Ending Page | 733 |
| Page Count | 3 |
| File Format | |
| ISSN | 00074888 |
| Journal | Bulletin of Experimental Biology and Medicine |
| Volume Number | 151 |
| Issue Number | 6 |
| e-ISSN | 15738221 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2011-10-13 |
| Publisher Place | Boston |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | gold nanoparticles micronucleus assay bone marrow mutagenic activity Internal Medicine Laboratory Medicine Pathology Cell Biology Biomedicine general |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Biochemistry, Genetics and Molecular Biology |
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