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| Content Provider | Springer Nature Link |
|---|---|
| Author | Khavinson, V. Kh. Nikolsky, I. S. Nikolskaya, V. V. Zubov, D. A. Galickaya, S. N. Taranuha, L. I. Semeva, Ya. M. A. Lisica, N. A. Linkova, N. S. Butenko, G. M. |
| Copyright Year | 2011 |
| Abstract | Tripeptides T-36 and, particularly, T-38 in concentrations of 0.1, 1, and 10 ng/ml inhibited proliferation of primary trypsinized embryonic mesenchymal stem cells, rat transplantable KF-1 fi broblasts, and human erythromyelosis K-562 cells. Inhibition of proliferation in embryonic and immortalized cells under the infl uence of tripeptides probably refl ects antitumor activity of these substances. Tripeptides had no effect on lymphocyte survival and their adhesive, cytotoxic, and induced proliferative activities. T-36 did not modulate the proliferative properties of erythromyelosis K-562 cells. Tripeptides did not change engulfment activity and spontaneous and induced bactericidal activities of granulocytes. T-36 in a concentration of 0.1 ng/ml increased spontaneous proliferation of normal lymphocytes. These data suggest that tripeptides stimulate nontumor immune cells in adult people. |
| Starting Page | 722 |
| Ending Page | 725 |
| Page Count | 4 |
| File Format | |
| ISSN | 00074888 |
| Journal | Bulletin of Experimental Biology and Medicine |
| Volume Number | 151 |
| Issue Number | 6 |
| e-ISSN | 15738221 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2011-10-12 |
| Publisher Place | Boston |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | tripeptides lymphoid cells mesenchymal stem cells proliferation Internal Medicine Laboratory Medicine Pathology Cell Biology Biomedicine general |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Biochemistry, Genetics and Molecular Biology |
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