NDLI: Destructive reactions of skeletal muscles in toxic metabolic injuries caused by bupivacaine in OXYS and wistar rats

Content Provider	Springer Nature Link
Author	Bakarev, M. A. Nepomnyashchikh, L. M. Kolosova, N. G.
Copyright Year	2007
Abstract	Universal types of muscle fiber injuries associated with characteristic changes in the myofibrillar system predominate in the spectrum of reactions to acute disorders of cell metabolism caused by bupivacaine. Quantitative parameters of the pathogenic exposure and structural and metabolic characteristics of the target fibers largely determine these changes: pronounced contractures involving primarily white muscle fibers, high incidence of disseminated and mixed forms, among which a special variant with predominant lytic processes (“cytolysis”) was distinguished. Minimum changes in the contractile system were often paralleled by diffuse destruction of mitochondria, which attested to the role of these organelles in the development of muscle fibers alteration in this model.
Starting Page	650
Ending Page	655
Page Count	6
File Format	PDF
ISSN	00074888
Journal	Bulletin of Experimental Biology and Medicine
Volume Number	143
Issue Number	5
e-ISSN	15738221
Language	English
Publisher	Springer US
Publisher Date	2007-01-01
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	metabolic injuries skeletal muscles bupivacaine OXYS rats polarization microscopy Biomedicine general Internal Medicine Cell Biology Pathology Laboratory Medicine
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry, Genetics and Molecular Biology

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Destructive reactions of skeletal muscles in toxic metabolic injuries caused by bupivacaine in OXYS and wistar rats