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| Content Provider | Springer Nature Link |
|---|---|
| Author | Gil, María Luisa Dagan, Shlomo Eren, Rachel Gozalbo, Daniel |
| Copyright Year | 2006 |
| Abstract | We have evaluated the effect of antibodies against the Candida albicans glyceraldehyde-3-phosphate dehydrogenase (GAPDH) as a potential immunotherapeutic treatment for acute invasive candidiasis in a murine model of infection. Three different approaches were assayed: (i) active immunization of mice using recombinant His-tagged GAPDH, (ii) treatment of fungal yeast cells with anti-GAPDH antibodies prior to infection, and (iii) passive transfer of polyclonal anti-GAPDH antibodies. Results showed that all three approaches, although tending to show a slight beneficial effect in some instances, fail to have a relevant and statistically significant effect on the infection course, determined by survival curves and fungal burden in kidneys. This suggests that the cell wall-associated GAPDH of C. albicans, despite its potential role in virulence, does not appear to be a suitable target protein for the development of immunotherapeutic strategies against candidiasis, although further studies may be required to confirm this observation. |
| Starting Page | 345 |
| Ending Page | 350 |
| Page Count | 6 |
| File Format | |
| ISSN | 00036072 |
| Journal | Antonie van Leeuwenhoek |
| Volume Number | 89 |
| Issue Number | 3-4 |
| e-ISSN | 15729699 |
| Language | English |
| Publisher | Kluwer Academic Publishers |
| Publisher Date | 2006-04-25 |
| Publisher Place | Dordrecht |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Anti-GAPDH antibodies Candida albicans Glyceraldehyde-3-phosphate dehydrogenase Immunization Immunoprotection Murine candidiasis |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Molecular Biology Microbiology |
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