NDLI: Increased numbers of small circulating endothelial cells in renal cell cancer patients treated with sunitinib

Content Provider	Springer Nature Link
Author	Vroling, Laura Veldt, Astrid A. M. Haas, Richard R. Haanen, John B. A. G. Schuurhuis, Gerrit Jan Kuik, Dirk J. Cruijsen, Hester Verheul, Henk M. W. den Eertwegh, Alfons J. M. Hoekman, Klaas Boven, Epie Hinsbergh, Victor W. M. Broxterman, Henk J.
Copyright Year	2009
Abstract	Mature circulating endothelial cell (CEC) as well as endothelial progenitor populations may reflect the activity of anti-angiogenic agents on tumor neovasculature or even constitute a target for anti-angiogenic therapy. We investigated the behavior of CECs in parallel with hematopoietic progenitor cells (HPCs) in the blood of renal cell cancer patients during sunitinib treatment. We analyzed the kinetics of a specific population of small VEGFR2-expressing CECs (CD45neg/CD34bright), HPCs (CD45dim/CD34bright), and monocytes in the blood of 24 renal cell cancer (RCC) patients receiving 50 mg/day of the multitargeted VEGF inhibitor sunitinib, on a 4-week-on/2-week-off schedule. Blood was taken before treatment (C1D1), on C1D14, C1D28, and on C2D1 before the start of cycle 2. Also plasma VEGF and erythropoietin (EPO) were determined. Remarkably, while CD34bright HPCs and monocytes decreased during treatment, CD34bright CECs increased from 69 cells/ml (C1D1) to 180 cells/ml (C1D14; P = 0.001) and remained high on C1D28. All cell populations recovered to near pre-treatment levels on C2D1. Plasma VEGF and EPO levels were increased on C1D14 and partly normalized to pre-treatment levels on C2D1. In conclusion, opposite kinetics of two circulating CD34bright cell populations, HPCs and small CECs, were observed in sunitinib-treated RCC patients. The increase in CECs is likely caused by sunitinib targeting of immature tumor vessels.
Starting Page	69
Ending Page	79
Page Count	11
File Format	PDF
ISSN	09696970
Journal	Angiogenesis
Volume Number	12
Issue Number	1
e-ISSN	15737209
Language	English
Publisher	Springer Netherlands
Publisher Date	2009-02-11
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Circulating endothelial (progenitor) cells Renal cell cancer patients Sunitinib VEGF Erythropoietin Oncology Ophthalmology Cardiology Cell Biology Biomedicine general Cancer Research
Content Type	Text
Resource Type	Article
Subject	Physiology Clinical Biochemistry Cancer Research

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